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Hello reddit. This is a long story so I'll try to keep it short, however, since the bug eludes me, I'll still provide quite a bit of background. Please bear with me.
Me: I'm 34 yo, have a small degree in IT (although I now work in healthcare, weirdly) and have built numerous PCs over the years without any kind of problems.
One of my colleagues asked me to help him build a new pc. He has a lot of money, but in an effort to keep his expenses to a minimum as well as to avoid non-necessary discarding of working equipment (ecology and such), I went to his home to evaluate the parts he had, to see if we could keep any. I inspect his PC, not much to keep because it's 7 years old and was prebuilt. When we go to hook it back up to his monitor, he looks suddenly upset. It turns out, each time he unplug his monitor or his pc from the wall plug, he has trouble getting his screen to output anything, and that he has to reboot sometimes for two-three hours in a row to get it to work. Over the next hour I tried every cable (HDMI and Displayport), in every port, on the motherboard and the gpu. At this point, I tell him it's not normal, it got to be his monitor. His wife chimes in and tells us he had this problem before having this monitor, and we notice his keyboard does not even light up. I go to get another monitor that I know works, and by the time I came back, he had it working, so we did not try with a new monitor. His keyboard was now lit.
In light of all this, probably because he was fed up (and because the keyboard not litting up had me worried it was the mobo), he decided to change every part of his computer but the HDD he uses for data (the HDD was fine, not corrupted sectors or anything, and it has never been used for the system install, only data), and to keep his monitor because I attributed his problem of no display (despite successful boot) on his mobo. After I laid out the options, he settled for this exact configuration:
Motherboard: Gigabyte Z690M DS3H
CPU: Intel Core i5-13600K
RAM: Corsair Vengeance RGB Pro 2 x 16GB, 3200 MHz, RAM DDR4, DIMM
Case: be quiet! Pure Base 500DX
GPU: EVGA GeForce RTX 3070 Ti FTW3 ULTRA
Ventirad: Noctua NH-D12L
PSU: Seasonic Focus GX 750 W (all 650 were out of stock when we ordered)
SSD: Samsung 870 EVO
+ His old HDD whose references I don't have.
+ His old monitor: a Millenium MD49 DHQD
So we receive all the parts, I build them like I always do: carefully. We set up everything so I can install his OS for him. And it does not work. Once again, no display, no lit keyboard, no POST despite the parts in the computers lighting up (RAM led, GPU lights) and fans turning on.
At this point I'm like ok, I had a suspicion it would happen, I brought the other monitor with me right away. We hook up the other monitor. It does not work at all. No POST, no signal, no boot, no nothing. That's when my colleague notice his keyboard does not even light up, exactly like before. Except we changed every single part.
So I took the damn thing home, and I rechecked everything, like so:
Compatibility: No problem, checked by reading the various manufacturer's documentation as well as pcpart picker.
Mobo : Spacers well aligned. No loose screws anywhere, no damage visible on mobo, was grounded while putting parts in place so no static electricity, did not put my finger on any sensitive area.
PSU: All powering wires are well in place, I did not forget the CPU power
Bent pins: No bent pin anywhere, not on the mobo, not on the CPU
CPU: The right amount of thermal paste, well in place in his socket, no sign of damage whatsoever, fan turns on when it should.
GPU: Plugged in the right amount of connectors, no sign of damage, fan turns on and light turns on.
Tried: unplugging every USB and booting up without the GPU. Plugging screen on GPU or on mobo (HDMI is all I've got, cable works)
Then I got some reaction:
RAM: First positioned according to the mobo manual. RGB Led on the RAM works. Then tested in every configuration possible, each stick tested in each slot individually, then swaped around. Tested another single stick I had spare but for which I cannot 100% guarantee the compatibility, still no nothing. At that point I decided to be a lil bit smart about it and plug in the mobo speaker (yeah it was a sunday morning, had not yet had my coffee). That's when it get extra weird: when the two sticks are positioned according to the mobo manual, when I turn on the power, for the first 45-50sec nothing happens, then 4 long beeps, and then the pc powers down and turns back on, and it happens indefinitely if you let it. The mobo use AMI Bios, and 4 long beeps means...nothing. After a good amount of search, the closest I've come to is 4 short beeps, meaning system timer failure. Or three short beep and one long, which means AGP error. But nothing for 4 long beeps.
At this point I try the various CMOS manipulation: powering down, unplugging, waiting a bit, taking the battery out, putting everything back, no change at all. Then I try the clear CMOS jumper, no change, still 4 long beeps happen, no POST, no display, keyboard still not lit up.
What I did not try: changing the battery, as I don't have any at home, but the card is new. Changing for two sticks of RAM that I am 100% sure work.
So I'm at a loss. Someone told me that his monitor might have short circuited the mobo, but I have a hard time believing it because his old computer was not toast, it "just" had trouble reckognizing signal after being unplugged, but as long as he only turned it off he had no trouble getting signal. So now I'm starting to believe there's two separate problems.
First: His old monitor (I say old but it is actually quite new) having what is probably connector trouble, because since then we've tried hooking a different computer to it, and we still get no display despite the other computer booting just fine and having a display on another screen.
Second: His new computer having one of the part that's defective. I'm thinking it's bad luck, not necessarily connected, and that we received a defective mobo. The 4 long beeps is puzzling me and before we send it back, I want to be extra sure that we send back the right part. Is there any insight that any of you could provide? Is it the mobo? The RAM? Could the problems be linked? Have I forgotten something very obvious?
What I plan on doing next beside posting here: Getting two sticks of RAM that I am sure work, getting another CMOS battery, if nothing works...I'll send back the mobo. But I have the unexplainable feeling there's something I'm missing.
Sorry for the wall of text, I tried to be as thorough as I could. Thank you for any amount of help or insight you can provide.
So I’m on episode two of Book II, Season 3 and personally I think Lorenzo has hardly any place in this story and his purpose is literally to be blackmailed by Cane. So much so that it happens only two episodes in and prior to that he has done next to nothing else.
In my opinion, I think they could of gone many other places with his story that involved more interest in his character and a more logical way of Cane finding out that Lorenzo killed Zeke. I get that Lorenzo wanted to be the one to be searching for Zeke’s killer so no one else would be close to it and he wouldn’t be caught. But then why would he ever take the risk of making Cane do it, I understand he doubts how smart Cane is but he’s not fucking brain dead, the pilot was easy to find and he got a description of the back of Lorenzo and the car. It’s just weird that Lorenzo would let Cane do it knowing how easy it would be to find out.
Personally, I think Lorenzo’s story in this season should have been tying up lose ends - using his resources to track down anyone who could have caught him whilst claiming he was “finding Zeke’s killer”. And whilst trying to tie up these lose ends someone in the family catches him but definitely later than the second episode. At least this way Lorenzo looks more ruthless and cold as he hunts down and kills any witnesses and also show off his powestreet connections. In my mind, this establishes Lorenzo as more than just a pawn and justifies how he could run an organisation without Monet.
There's this girl who's been my friend for almost 10 years. We've been very close for a long time and she's known for having lots of physical and mental health problems. Over the years, she's been through many traumatic events. However, a few years ago, I started noticing that the version she gave me was not always quite the same as the one she gave other friends of ours. These differences seemed like little details but it bugged me. To name a few: - She had an ovarian issue, not sure what it was. She told me it was just a tiny mass, she told another friend doctors told her it was cancer - She's had trouble going through uni because of her mental health but told me she had arrangements with the administration to be able to pass her classes. She even told me she was teaching a class of first years as a teacher's assistant. Turns out I discovered she never even got her Bacheeelor's degree (she shared classes with a friend of mine and, when the university published the list of the graduates' names, she wasn't in it. I even looked through the other years' lists to be sure she was supposed to graduate that year, never found her name).
On top of that, every single time she goes through something, it has to happen the worst way possible (every time she goes to a hospital, the staff is horrible to her, she gets hit on by male nurses, the doctors don't take care of her properly etc.)
All of that aside, she still is one of my closest and best friends, the kind you can tell anything to and will never be judged or let down by.
My question is: Am I an asshole for second guessing awful things she tells me? I want to believe her, and most of the time I do at first, but I can't help wondering if what she tells me is a 100% true, altered to make it more interesting, or a 100% false. I feel like she's doing that because she likes to be pitied and wants to show everyone she has it worse than them, and I refuse to condone that.
TL;DR: I feel like my best friend doesn't always tell me the truth about awful things that happen to her and I second guess everything she tells me. Am I an asshole?
Thanks for readinge
Detective Smith had been working on the case for months, but no matter how hard he tried, he couldn't seem to find a lead. The case involved a missing person, a wealthy businessman who had vanished without a trace.
Smith had interviewed dozens of people, from the victim's family to his business associates, but none of them had any idea what had happened to him. There was no ransom demand, no sign of a struggle, and no indication that the victim had planned to disappear.
As Smith sat in his office, staring at the pile of case files on his desk, he received a phone call. It was a woman who claimed to have information about the missing person. She refused to identify herself, but she told Smith to meet her at a secluded location outside of town.
Smith arrived at the location and waited, but no one showed up. As he was about to leave, he noticed a piece of paper on the ground. It was a note, written in a shaky hand, that read, "He's not missing. He's gone."
Smith was puzzled by the note. Who had written it, and what did it mean? Was the missing person dead, or had he chosen to disappear on his own? And why had someone gone through the trouble of luring Smith to the location just to leave a cryptic note?
As Smith drove back to his office, he knew that the case was far from over. The note had raised more questions than answers, and he couldn't shake the feeling that there was something he was missing. But for now, he had to keep digging, keep searching, and keep trying to unravel the mystery of the missing person.
The Woodroof Protocol A method of reducing withdrawal, support tapering and prevent relapse I dedicate this work to everyone struggling with addiction as well as those, helping the increasing number of people, out there suffering. From the parent worried sick about their child, to the healthworkers and professionals each Day fighting to save the lives of those, still stuck in addiction.
My dear American friend whom I had the pleasure of getting to know and helping to taper
from a severe opiod-addiction, inspired me to write this to share with you.
This information will be of great value, if you’re trying to recover, or currently helping
someone, recover from addiction to: stimulants, opioids and GABAergics.
Here below is a short guide, that summarizes the findings made from Years of experience
working within this field making personalized regimens of supplements with very promising
The individual regimens are all legal, non-toxic, non-addictive, natural and most importantly
based on evidence. They can all be bought or ordered online, at a reasonable cost and self
administered or used alongside other treatments etc. Introduction:
I wanted to show my appreciation for Woodroofs work and courage making treatments
available back then, fighting for the rights of people, who weren’t offered the best
treatment they knew at the time.
Woodroof is a referal to Ronald Dickson Woodroof (1992) who founded the famous Dallas
Buyers Club which later was made into the movie by the same name. R.D.Woodroof through
the buyers club, distributed medicine to treat Aids during the hardship in the 80’s. Today we
see addiction is killing more people each Year than Aids did when it was most rampant in the
US. Not only OD’s but addiction-related suicide as well as alcoholism is widely spreading,
creating torn apart families and isolated individuals, all who are in dire need of our help.
This story ressonated with me, as I started a non-profit myself about 3 Years ago, where we
collectively bought large amounts of supplements to save money and to get around the
legislation in my country. I would then make personalized blends of these for a lot of cases,
but especially for people struggling with addiction and cases where our psychiatry had failed.
I quickly started getting people referred to me struggling with stimulants, opioids and
GABAergics but were also able to help in a lot cases with somatic diseases and I had to keep
learning and read up on the studies as well as scout the internet for knowledgeable sources.
I was educated as an intercultural and international socialworker, later having studied
anthropology and globalization, although I have no background in medicine, this must be
I suffered a minor TBI (traumatic brain injury) 10 Years ago, and I had to learn, how to
recover from the cognitive issues and did a lot of experimentation and researched neuro
regeneration and supplements for Years which meant I was familiar scouting for resources, reading studies as well as looking for interactions.
I needed to dive deep into the individual effects of minerals, vitamins, amino acids,
adaptogens and nootropics and the different synergies, and found some very interesting
finds regarding possible addiction treatments and support, and I have witnessed some very
These following regimens and advice is what I’ve seen having the highest rate of recovery as
well as the lowest rapported issues with relapse, accute withdrawal as well as PAWS (post
accute-withdrawal-symptoms) while and after tapering. Studies are linked beneath each, for
further reading. If you’re on any other medication or supplements, then either get a medical professional to look into interactions before trying any of these or if you proceed on your own hand, make sure either ask on i.e. Reddit / FB groups, or Google substance-x + substance-y + interactions and do a bit of reading. I. Opiods
Warning, this blend of supplements potentiates opiates to a high degree, meaning if you’re
on an active taper, then dose lower than you’re used to before trying these, approximately
half your usual dose. It also means you can do a far more rapid taper and use these before,
as well as after, your last dose during the taper, to reduce RLS and PAWS here. When you
hit a wall and your body starts reacting with WD’s, then hover at that dose for a few Days
and then continue cutting down a little less aggressive from there on.
- Bacopa Monnieri Extract_______________________300mg-3000mg pr. Day in 1-4 doses
- Black Seed Oil (Nigella Sativa) ___________________1 tbsp.-3 tbsp. pr. Day in 1-4 doses
- Agmatine ___________________________________500mg-1500mg pr. Day in 1-4 doses
- Vitamin C (Sodium Ascorbate)_____________50mg-100mg pr.kg divided in several doses*
*Before starting the vitamin C, I recommend to read up on this link: https://ericazelfand.com/vitamin-c-for-opioid-addiction/
If you suffer from hemochromatosis, skip the vitamin c though.
*In some cases where you’re coming off a dangerously high dose of fentanyl or methadone,
then substituting with kratom alongside this regiment can be useful in certain cases, but it
must be said kratom in of itself is an opioid with risk of addiction. It’s the lessor of two evils
though and for some can have benefits, if they can’t get suboxone etc. It will work fine,
alongside this taper as these supplements also potentiates the kratom and suboxone a lot. If
you’re trying to get off kratom the same supplements will help you too.
Bacopa (BM) can require a step by step increase to avoid stomach issues, so start with a low
dose. Some people get slight diarrhea dosing high on BM, so always dose right after a fatty
meal, or just use Psyllium husks and some butteoil before taking the BM, although a large
meal containing fats, is the most effective way mitigating this. Also certain bad extracts
tends to make the diarrhea inevitable even in low doses and with food so if you’re unlucky
to get your hands on a bad extract, try giving another a go before you give up on BM as it is
truly effective when it can get absorbed. Both the vitamin c and the BM needs to get adjusted for by slowly increasing until you reach
bowel tolerance. A meal before, with the fiber and fats seems to shorten this period.
BM in higher doses causes a slight fatigue and some prefer to take 200-500mg of rhodiola
extract early in the Day to counter this because if the rhodiola is taken late, it will hinder
Bacopa has a long history of use for opium-addiction in India but have recently been studied
and hailed for it’s effect of diminishing discomfort and reducing WD’s as well as the dose
needed for painrelief etc. Agmatine and BSO also show great potential for reducing WD’s
and managing PAWS as shown in the studies.
I will refer to a few studies here but for more detailed information, I recommend reading or
skimming the PHD dissertation about the potential of bacopa in opioid dependency as well.
For further reading on each supplement Google each + opioid + studies or opiates, and read
about some of the studies or old threads about these.
Effect of bacopa monnieri on morphine dependence and tolerance to analgesia in
animal models (PHD Thesis) http://prr.hec.gov.pk/jspui/bitstream/123456789/2010/2/1574S.pdf
Effect of Bacopasides on acquisition and expression of morphine tolerance https://www.researchgate.net/publication/50289046\_Effect\_of\_Bacopasides\_on\_acqui
A new and novel treatment of opioid dependence: Nigella sativa 500 mg https://pubmed.ncbi.nlm.nih.gov/19385474/
Thymoquinone: From Nigella sativa to a protective pharmacological compound in
managing opioid dependence and amphetamine type stimulant issues https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395189/
Effect of agmatine on the development of morphine dependence in rats: potential role
of cAMP system https://pubmed.ncbi.nlm.nih.gov/15541421/
Agmatine Prevents Adaptation of the Hippocampal Glutamate System in Chronic
Morphine-Treated Rats https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563829/
Attenuation of heroin withdrawal syndrome by the administration of high-dose vitamin
I recommend to continue this regimen for a while after seizing the last mg’s of opiates as
this prevents relapse by a great deal as well as helps to bring the body back into homeostasis
as bacopa increases synaptogenesis as well. You can skip the high dose vitamin C when
you’re out of the woods and just get a good multivitamin and some omega 3’s to maintain
the effects. The rhodiola also acts as a powerful anti-fatigue and anti-depressant for post
addiction lethargy. Most get great relief from doing this regiment for longer periods as they
report it helps keep them clearminded and manages their cravings for opiates, is what I’ve
experienced from feedback. The doses can easily be lowered to more sustainable levels that will still offer relief from
cravings. On the last page I have some recommendations for other natural compounds with
neuro-regenerative proporties that also reduces cravings for alcohol and drugs that can be
worth looking into to add to, as well as substitute for some of these when you get clean and
free from WD’s again. II. Stimulants
Warning, do not use mucuna alongside an active taper still using stimulants. You should be
able to stop or do a rapid taper with the others and continue with the mucuna but do so
only, when you’re off the stimulant. In most cases it is easier just to stop and substitute with
this regimen as it will reduce cravings, mental instability as well as physical WD’s very
effectively. Also be aware that polygala potentiates stimulants so dose lower than usual
around 2/3 normal dose and monitor your reactions if you are going to taper off without
mucuna. If any sign of discomfort arises, wait to use polygala also until you’ve tapered down
using the others.
- L-tyrosine____________________________________________500mg-2500mg 1-3 doses
- Bilberry/Blueberry Extract_______________________________300mg-1500mg 1-3 doses
- Polygala Extract_______________________________________ 50mg-200mg 1-3- doses
- Mucuna Extract________________________________________50mg-250mg 1-3 doses
Mucuna extract contains l-dopa which is a direct precursor to dopamine and l-tyrosine is a
precursor to l-dopa, which helps prevent neurotoxicity to some degree. Bilberry/blueberry
extract also has neuroprotective proporties on the dopaminergic system as shown from the
studies below. It’s best to get bilberry as it contains 4-10x higher the amount of
anthocyanins but a higher dose of blueberry extract will also work. It is though not
recommended to use mucuna for lengthy periods due to risk of neurotoxicity so later, you’ll
be able to, instead drop the mucuna, and add NAC + d-phenylalanine which is a precursor to
the l-tyrosine, alongside the others. This is once you’ve been clean for at least a Week and
managed the most severe craving and WD’s.
In case you’re showing troubling signs of brainaging due to stimulant-use, you can add
bacopa to this stack as well, as evidence is showing it is acting as a powerful neuroprotectant
in meth+mpp induced neurotoxicity and it’s effect of synaptogenesis will aid here, as well.
Pair it with rhodiola 200-500mg if you experience fatigue or depression from the PAWS that
won’t dissapate with the supplements.
Antioxidant-Enriched Diet Affects Early Microglia Accumulation and Promotes
Regeneration of the Striatal Dopamine System after a 6-Hydroxidopamine-Induced
Lesion in a Rat https://journals.sagepub.com/doi/10.4137/JEN.S10424
Blueberry- and spirulina-enriched diets enhance striatal dopamine recovery and induce
a rapid, transient microglia activation after injury of the rat nigrostriatal dopamine
Dopamine mediated antidepressant effect of Mucuna pruriens seeds in various
experimental models of depression https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213977/
Neuro-Cognitive Effects of Acute Tyrosine Administration on Reactive and Proactive
Response Inhibition in Healthy Older Adults https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084775/
Tyrosine influence on amphetamine self-administration and brain catecholamines in the
Effects of dietary tyrosine on L-dopa- and amphetamine-induced changes in locomotor
activity and neurochemistry in mice https://pubmed.ncbi.nlm.nih.gov/2080188/
Polygalasaponins effective against antipsychotic treatment https://patents.google.com/patent/KR100378323B1/en
Antidepressant Principles of the Roots of Polygala tenuifolia https://www.researchgate.net/publication/6804019\_Antidepressant\_Principles\_of\_the
Hypothesizing Balancing Endorphinergic and Glutaminergic Systems to Treat and
Prevent Relapse to Reward Deficiency Behaviors: Coupling D-Phenylalanine and N
Acetyl-L-Cysteine (NAC) as a Novel Therapeutic Modality https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760695/
I also recommend you continue this regiment for as long as you experience cravings or fear
you might relapse. Just switch the mucuna after the critical phase and instead use NAC + d
phenylalanine and perhaps bacopa if there’s some damages from a long period of addiction.
You will easily be able to find a lower or even a higher, functioning dose of the supplements
that suits your need for repair and relief. The most important part is you move further and
further away from relapse and get the natural energy and drive to get back into a healthy
lifestyle again. In general people I learn who’ve forgotten or stopped their supplements,
after they get clean, tends to relapse, way more often, than those who keep their regimens.
So use this for as long as needed and read the part about alcohol and managing cravings
down at the bottom. If you feel some resistance to using supplements or want to learn more
about other kinds of medicine like these, I advice you to download the free guide, linked to
at the last page. III. GABA ’ergics
Warning, don’t completely seize your use of benzodiazepines abrubtly. Plan a careful taper
as risk of seizures can be highly dangerous, especially in the higher dose-range. This regimen
will potentiate benzodiazepines also, as well so be aware to dose lower in the beginning
until you get a sense of how much potentiation, for the benzo, you’re currently on.
Approximately to 1/2 and then if WD’s kick in dose a bit higher until you feel okay and if you
get high vice versa. If you’re using a benzo that is metabolized fast like alprazolam it can be
worth to slowly adjust and start using a benzo with a longer half life like clonazapam and
diazapam to better be able to cut doses and not worry about getting into WD’s at every hour. Emoxypine________________________________________100mg-500mg 1-3 doses pr.Day
Agmatine_________________________________________500mg-1500mg 1-3 doses pr.Day
Magnolia Bark Extract_______________________________200mg-800mg 1-3 doses pr. Day
Black Seed Oil (Nigella Sativa)______________________1 tbsp.-3 tbsp. 1-3 doses pr. Day
*This also works for gabapentenoids like (Gabapentin, Pregabalin and Phenibut) but if
you’re tapering down from a high dose phenibut, you might also benefit by substituting 1g
of phenibut with 10mg baclofen in that ratio. This regimen will make you able to taper fast
and effective down from the baclofen too.
Glutamate surges from excitotoxicity when tapering, often creates severe adrenal fatigue,
mental instablity and wearyness, after a while and here it is also important to make sure to
get a enough vitamin b6 and you’ll also be able try kava, NAC and l-theanine, alongside this,
to prevent these symptoms. Magnolia modulates GABA-a but there’s not many studies on
emoxypine even though safety has been well-established. Regarding emoxypine, you can
find a wide arrange of user reports that backs it’s efficiency in tapering which were
confirmed from my own observations.
All of these together, can bring a bit symptoms of fatigue due to the combined effects of the
supplements. If this becomes an issue take 200-500mg of rhodiola extract early in the Day to
counter this because if the rhodiola is taken late, it will hinder sleep. Lemon balm and
magnesium glycinate can be a help in getting some sleep, in certain phases in the WD’s if
you taper aggressively.
Use this like the other regimens for as long as you need the support and when you’re
completely off all benzodiazepines and stabilized, then you can switch the magnolia extract
to sabroxy extract, and this will help your brain heal faster due to increased BDNF,
neurogenesis as well as synaptogenesis. Bacopa too has effects of synaptogenesis and will
help mitigating symptoms of alcohol WD and craving and can be useful to add, once you’re
off as well.
Benzo induced neurological dysfynction (BIND) can require more of the neuro-regenerative
effects in general and higher doses. I suggest you download the free guide, linked to at the
last page, and look into, sabroxy, polygala, bacopa, sulforaphane, emoxypine and the
neuropeptides as a start.
Agmatine Inhibit The Tolerance To The Anxiolytic Effect Of Diazepam In Rats https://www.semanticscholar.org/papeAgmatine-Inhibit-The-Tolerance-To-The
Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, induces
sleep via the benzodiazepine site of GABAA receptor in mice https://www.sciencedirect.com/science/article/abs/pii/S0028390812002894
Effect of Magnolia officinalis and Phellodendron amurense (Relora (R)) on cortisol and
psychological mood state in moderately stressed subjects https://www.researchgate.net/publication/255705487\_Effect\_of\_Magnolia\_officinalis\_
in_moderately_stressed_subjects Promising effects of emoxypine and its succinate derivative in the management of
various diseases-with insights on recent patent applications https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389226/
[The results of the study of the efficacy and safety of mexidol in patients with chronic
cerebral ischemia] (Mexidol = Emoxypine) https://pubmed.ncbi.nlm.nih.gov/26081329/
Kava as an anticraving agent: preliminary data https://www.researchgate.net/publication/11205899\_Kava\_as\_an\_anticraving\_agent\_
Bacopa monnieri abrogates alcohol abstinence-induced anxiety-like behavior by
regulating biochemical and Gabra1, Gabra4, Gabra5 gene expression of GABAA receptor
signaling pathway in rats https://www.sciencedirect.com/science/article/pii/S0753332218383914 III. I.Alcohol
Dealing with alcoholism often get’s tricky as this is tied deeply into culture as well as
patterns of engaging in much needed socializing.
This regimen of supplements might be able to reduce most of the cravings and help with
many of the issues from a physiological point of view. While on the other hand, the isolation
and mental toll it takes to step outside of the festivities, often tend to push people back into
drinking or worse even, into drugs.
Kava shows some very promising results being a positive allosteric modulator of the GABA-a
receptor which means it doesn’t have much addiction potential at all, yet mimicks a lot of
the effects from alcohol. In a lot places now, people are beginning to bring kava for
themselves for going to parties, to manage social anxiety and peer-preassure as well as
experiencing the enjoyment of being a part of the letting loose.
Kava has shown to act as a powerful anti-cravings agent as shown in the study below, not
only for alcohol but most drug of choices tested on the group. My anecdotal observations:
Most people who’ve gotten clean, functional and even stopped drinking due to it leading
them to do drugs, often told me about them getting a nagging evening restlessness. In
general how it would get their head spinning about relapsing just once etc.
Those who tried kava all reported that it took away that sense of craving and it helped them
relax and unwind when they got stressed enough to begin fantasizing about drugs and
alcohol. Some of those who didn’t want the kava, managed to stay clean, while others
unfortunately found themselves, slip a few times.
But they often reported, that having the supplements and knowing the way back, kept them
getting back to living clean very quickly after.
A theory of this is, could be due to the role alcohol and cannabis has played for thousands of
Years perhaps, being incoded in our biology, to come to a point where the need, for just
some kind of recreational effects for some, becomes highly unbearable to cope with.
This is why I often advice people in risk, to get to learn about kava and have at least a little
bag of instant/micronized kava lying around, so they know they’ll be able to push the panic
button on the accute cravings.
The point of kava being highly adviced as the lessor of two evils is displayed in these
infographics here: (https://sci-hub.st/10.1177/0269881119841569
) Kava and safety:
Kava got a bad stain from back in the 90’s when some medicinal companies bought up a
kava-company and shortly after started making acetone extracts of leaves and stems which
wasn’t allowed. A few cases with people with pre-existing liver issues and even alcoholism
and medication on the side, in a rare instants experienced hepatoxicity and the pharmaceutical industry, in a collective effort, blew it out proportions. The most likely cause
of this, is hypothesized to be, the rapid increase, in loss of sales of benzodiazepines and
addictive sleeping medication, which they began seeing as kava increased in popularity back
in the late 90’s. Multiple peer-reviewed studies have since put these claims to rest, and
these are linked to beneath. As a comparison acetylsalicylic acid, also known as aspirin, was
actually found, to be more dangerous than kava.
“Kava Lebertoxisch?” DAZ.online. https://www.deutsche-apotheker-zeitung.de/.../uid-
“Kava Toxicity.” https://doi.org/10.1046/j.1442-2026.2000.00107.x
“A Plant Kavalactone Desmethoxyyangonin Prevents Inflammation and Fulminant
Hepatitis in Mice.” https://doi.org/10.1371/journal.pone.0077626
“Kava Feeding in Rats Does Not Cause Liver Injury nor Enhance Galactosamine-Induced
Hepatitis.” . https://doi.org/10.1016/j.fct.2007.01.015
“Lack of Evidence of Kava-Related Hepatotoxicity in Native Populations in Savaii,
“Yangonin Protects against Non-Alcoholic Fatty Liver Disease through Farnesoid X
Receptor.” Phytomedicine: International Journal of Phytotherapy and
“Effects of Kava Root Extract on the Liver Morphology of c57bl-6 Mus Musculus Mice.”
“Anxiolytic Action and Safety of Kava: Effect on Rat Brain Acetylcholinesterase Activity
and Some Serum Biochemical Parameters. http://dx.doi.org/
“Chemical and in Vitro Toxicity Analysis of a Supercritical Fluid Extract of Kava Kava
(Piper Methysticum).” https://doi.org/10.1016/j.jep.2019.01.032
“Flavokawains A and B from Kava (Piper Methysticum) Activate Heat Shock and
Antioxidant Responses and Protect against Hydrogen Peroxide-Induced Cell Death in
HepG2 Hepatocytes.” https://doi.org/10.3109/13880209.2015.1107104
“Aqueous Kava Extracts Do Not Affect Liver Function Tests in
“Safety of Ethanolic Kava Extract: Results of a Study of Chronic Toxicity in Rats.”
“Kava Hepatotoxicity: Comparative Study of Two Structured Quantitative Methods for
Causality Assessment.” . https://doi.org/10.1111/j.1365-2710.2009.01131.x
. Finishing words:
Reintegrating your lifepath back into your original flowstate again, can be difficult, as all
addiction tends to originate from trauma of some sort, but also create a lot of trauma in of
itself. Most of us, are also carriers of multiple generations of traumatic experiences and all of this, if not treated, will hinder our journey into the higher levels of emotional and spiritual
growth. These regimens can provide us with a long window of opportunity to begin to find
your way back into progressing with a healthy lifestyle. But if the addiction-issue, is taken
lightly, and given enough time, the signs of trauma’s will come clawing their way back and
have you risk relapse.
I see a lot, find great comfort in religious community with a strong faith as well as evolving
values of reciprocity to newcomers. Some start to exercise a lot and eat healthy again, as
well as reach out to new friendgroups. Some show great benefits from getting therapy or
counseling for that extra assistance in unraveling, certain kinds of severe trauma. Others go
into Eastern and spiritual practices like Qigong and Yoga and start to meditate. A
combination of all of these would be ideal, but focus on one step at a time. There are many
paths back to healing and a good marker for progression here, is if your eyes are getting
kinder, your voice is becoming softer and you begin to feel and see the traumas, of others,
and wants to be in service of some sort.
A short story we can use to remind ourselves. A long time ago, a therapist explained to me. "Once a woman told me that she would always love being intimate with her husband because then after that his eyes would be mild and kind. A man then told me how he loved making his wife laugh, because after that, her voice would become soft and playful. Lastly a young child told me, how the child loved being around and being in service to the parents, because after that, they would listen and stay present, just as ready to cry with them as to laugh with the them. Counter-intuitive strategies
For those who at some point will seek out, some kind of therapy this here beneath, might be
PTSD therapy offers relief for around 20% of people with PTSD, while MDMA-facilitated
therapy shows results of around 80% instead. If you suffer from PTSD or severe trauma, and
you can’t get this therapy where you’re at, using kanna extract (preferably MT55) and
getting a good therapist to work with, will help you up the percentages. This is because
kanna works very similarly to MDMA. Just let the therapist know politely, that you’re
supplementing with a herbal extract while you’re there, to treat your anxiety, and most will
have no issues with this.
The promising aspect of this, is that now, you can have Weekly sessions instead of having to
wait 2-3 Months in between each, as with MDMA due to sideeffects and toxicity. Although
be careful that the euforic effects of kanna doesn’t act as a trigger so be mindful about this
The safety and efficacy of ±3,4-methylenedioxymethamphetamine-assisted
psychotherapy in subjects with chronic, treatment-resistant posttraumatic stress
disorder: the first randomized controlled pilot study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122379/
Acute Effects of Sceletium tortuosum (Zembrin), a Dual 5-HT Reuptake and PDE4
Inhibitor, in the Human Amygdala and its Connection to the Hypothalamus https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828542/
A Chewable Cure “Kanna”: Biological and Pharmaceutical Properties of Sceletium
This picture below, can be a great opener in the first stages of acknowledging and
understanding our trauma.
Credit for picture: u/imabritnotayank
(Reddit) Further reading:
You can find a more comprehensive guide on these and other supplements as well as good
places to buy from and save money etc. called: A Short Guide To Using Powerful Healing
Medicines In A Modern Age, on this link. https://fastupload.io/GPMqH19NazVNJNk/file
If the link stops working or if you have any inquiries, reach me on this email, I’ll try answer
within a few days : [email protected]
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