Usually around the first of the month we have a batch of price changes and this month is no different. According to the "How to Become a Contract Liquor Agent" document, "The Agent must also complete price changes that occur at the first of the month..."
The changes today seem to be mostly price decreases, some with a corresponding change to De-Listed status which suggests they're now "Last Call" products. There are also quite a few new products. I had to separate Vodka changes into its own reply below.
I plan to reply to this post throughout the month if I notice other significant changes happening or at the end of the month before the next update to keep the changes in one place. Here's a link back to what changed in March 2023.
For each category I've sorted by the amount of the price increase or decrease. New products are shown first, then price decreases are shown in decreasing order followed by price increases in increasing order. At the end are products with other changes unrelated to price.
Current product status is indicated on each line as follows. OHLQ hasn't publicly explained what these things mean but I've included my best guess below.

• A = Active
  • Regularly supplied and available for purchase
• D = De-Listed
  • No longer carried by OHLQ, may still be available in some stores or the warehouse. Sometimes considered a Last Call product
• I = Inactive
  • Discontinued by the supplier or otherwise unavailable to OHLQ
• S = Special Order
  • Regularly available but in limited supply. Not available in very many stores
• V = Value-Added-Pack
  • Bottle comes with some kind of extra gift like a glass/mug/etc

American Whiskey

• New Products
• [A] 291 COLORADO BOURBON WHISKEY BARREL PROOF SINGLE ($95.36 / 750 ML)
• [A] 291 COLORADO WHISKEY BARREL PROOF SINGLE BARREL ($95.36 / 750 ML)
• [A] A.M. SCOTT DISTILLERY SCOTTY'S BOURBON WHISKEY ($39.99 / 750 ML)
• [A] A.M.SCOTT DISTILLERY FOUNDER'S SELECT BOURBON ($59.99 / 750 ML)
• [A] BARDSTOWN BOURBON COMPANY ORIGINS RYE ($69.99 / 750 ML)
• [A] BARDSTOWN FOUR SQUARE COLLAB ($159.99 / 750 ML)
• [A] BERNHEIM WHEAT BARREL PROOF ($64.99 / 750 ML)
• [A] BRAIN BREW DEXTER SMALL BATCH WHEAT ($59.97 / 750 ML)
• [A] BUZZARD'S ROOST CHAR 1 BOURBON ($54.99 / 750 ML)
• [A] BUZZARD'S ROOST CHAR 1 RYE ($45.99 / 750 ML)
• [A] CEDAR RIDGE STRAIGHT BOURBON WHISKEY ($32.99 / 750 ML)
• [A] CHICKEN COCK DOUBLE OAK BOURBON ($99.99 / 750 ML)
• [A] CLERMONT STEEP AMERICAN SINGLE MALT ($59.99 / 750 ML)
• [A] ECHO SPIRITS DISTILLING CO BARREL PROOF BOURBON ($49.99 / 750 ML)
• [A] ECHO SPIRITS DISTILLING CO BARREL PROOF RYE ($49.99 / 750 ML)
• [A] ECHO SPIRITS DISTILLING CO BOURBON WHISKEY ($38.99 / 750 ML)
• [A] EZRA BROOKS 99 RYE ($24.99 / 750 ML)
• [A] FIVE TRAIL BLENDED AMERICAN WHISKEY ($49.99 / 750 ML)
• [A] FOX & ODEN AMERICAN SINGLE MALT WHISKEY ($69.99 / 750 ML)
• [A] FOX & ODEN STRAIGHT BOURBON WHISKEY ($89.99 / 750 ML)
• [A] GREEN RIVER BOURBON ($34.99 / 750 ML)
• [A] GREEN RIVER WHEATED BOURBON ($34.99 / 750 ML)
• [A] HAYNER HONEY RYE WHISKEY ($59.95 / 750 ML)
• [A] HAYNER MAPLE RYE WHISKEY ($59.95 / 750 ML)
• [S] HEAVEN HILL HERITAGE COLLECTION 2ND EDITON ($289.99 / 750 ML)
• [A] HIGH N' WICKED 5YR CASK STRENGTH BOURBON ($89.99 / 750 ML)
• [A] HIGH N' WICKED 5YR KY STRAIGHT RYE WHISKEY ($79.99 / 750 ML)
• [A] HIGH N' WICKED KY STRAIGHT BOURBON ($79.99 / 750 ML)
• [S] JACK DANIELS SINGLE BARREL PC BARREL PROOF ($65.99 / 750 ML)
• [S] JACK DANIELS SINGLE BARREL PERSONAL COLLECTION ($49.99 / 750 ML)
• [A] LAKE ERIE MAPLE WHISKY ($51.54 / 750 ML)
• [A] LAKE ERIE WHISKY ($28.51 / 750 ML)
• [A] MICHTER'S SMALL BATCH SOUR MASH ($48.99 / 750 ML)
• [A] NORTHERN YANKEE SUGAR SHINE ($34.99 / 750 ML)
• [A] NULU DOUBLE OAKED SMALL BATCH BOURBON ($84.99 / 750 ML)
• [A] OAK & EDEN BOURBON & BREW ($52.99 / 750 ML)
• [A] OAK & EDEN WHEAT & HONEY ($52.99 / 750 ML)
• [A] OLD ELK CIGAR CUT ($129.99 / 750 ML)
• [A] OLD ELK WHEAT N RYE ($99.99 / 750 ML)
• [A] PENELOPE ROSE CASK ($69.99 / 750 ML)
• [S] PENELOPE ROSE CASK PRIVATE BARREL ($79.99 / 750 ML)
• [A] PINHOOK HIGH PROOF RYE WHISKEY ($49.99 / 750 ML)
• [S] RABBIT HOLE CAVEHILL SINGLE BARREL ($149.99 / 750 ML)
• [A] REBEL 100 RYE ($21.99 / 750 ML)
• [A] SAGAMORE SPIRIT ($79.99 / 750 ML)
• [A] SMOKE WAGON SMALL BATCH BOURBON WHISKEY ($47.33 / 750 ML)
• [A] SMOKE WAGON STRAIGHT BOTTLED IN BOND RYE WHISKEY ($57.44 / 750 ML)
• [A] SMOKE WAGON STRAIGHT MALTED BARLEY RYE WHISKEY ($68.40 / 750 ML)
• [A] SMOKE WAGON STRAIGHT WHISKEY BOURBON ($25.42 / 750 ML)
• [A] SMOKE WAGON UNCUT THE YOUNGER BOURBON WHI ($36.37 / 750 ML)
• [A] SMOKE WAGON UNCUT UNFILTERED BOURBON WHISKEY ($65.03 / 750 ML)
• [A] UNCLE NEAREST SINGLE BARREL WHISKEY ($79.99 / 750 ML)
• [A] VON PAYNE BLACK ($59.97 / 750 ML)
• [A] WATERSHED UNCUT UNFILTERED BOURBON ($69.99 / 750 ML)
• [A] WHISTLEPIG BEHOLDEN 21 YR. OLD ($800.00 / 750 ML)
• [S] WHISTLEPIG PIGGYBACK RYE SINGLE BARREL ($59.99 / 750 ML)
• [A] WHISTLEPIG PIGGYBACK RYE BROTHER OSBORNE SERIES ($49.99 / 750 ML)
• [A] WHISTLEPIG PIGLETS ($24.90 / 50 ML)
• [A] WOODSTONE CREEK RIVER CITY BLACK LABEL ($37.99 / 750 ML)
• [A] YELLOWSTONE AMERICAN SINGLE MALT ($54.99 / 750 ML)
• Price decreases
• [D] KENTUCKY OWL BOURBON ($149.99 / 750 ML) - $150.00↓, Special Order to De-Listed
• [D] WILD TURKEY MASTER'S KEEP BOTTLED IN BOND 17 YEAR ($99.99 / 750 ML) - $100.00↓, Special Order to De-Listed
• [D] ELIJAH CRAIG 23 ($99.99 / 750 ML) - $99.99↓
• [D] AMADOR 12 YEAR BOURBON ($74.99 / 750 ML) - $50.00↓, Special Order to De-Listed
• [D] SAM HOUSTON 14 YEAR OLD BOURBON ($71.99 / 750 ML) - $48.00↓, Special Order to De-Listed
• [D] OLD ELK RYE WHISKEY ($59.99 / 750 ML) - $40.00↓, Special Order to De-Listed
• [D] SAM HOUSTON KENTUCKY STRAIGHT BOURBON WHISKEY ($59.99 / 750 ML) - $40.00↓, Special Order to De-Listed
• [D] JEFFERSONS TWIN OAK SMALL BATCH ($50.99 / 750 ML) - $34.00↓, Special Order to De-Listed
• [D] REMUS REPEAL RESERVE IV ($50.99 / 750 ML) - $34.00↓, Special Order to De-Listed
• [D] RANSOM THE EMERALD 1865 WHISKEY ($49.49 / 750 ML) - $32.50↓, Special Order to De-Listed
• [D] UNCLE NEAREST MASTER BLEND EDITION ($44.99 / 750 ML) - $30.00↓, Special Order to De-Listed
• [S] WIDOW JANE LUCKY 13 SMALL BATCH BOURBON ($99.99 / 750 ML) - $25.00↓
• [D] NASHVILLE BARREL CO SMALL BATCH RYE ($35.99 / 750 ML) - $24.00↓, Active to De-Listed
• [D] BACK ROOM DEAL HUDSON PEATED RYE ($32.99 / 750 ML) - $22.00↓, Active to De-Listed
• [D] BAKER BIRD ($32.99 / 750 ML) - $22.00↓, Active to De-Listed
• [D] ROSSVILLE UNION BARREL SELECT RYE WHISKEY ($32.99 / 750 ML) - $22.00↓, Special Order to De-Listed
• [A] BOURBON LEGENDS GIFT ($29.99 / 375 ML) - $20.71↓
• [D] JEFFERSONS CHEFS ($34.99 / 750 ML) - $15.00↓, Active to De-Listed
• [D] SMOOTH AMBLER OLD SCOUT RYE CASK ($34.99 / 750 ML) - $15.00↓
• [D] STRAIGHT EDGE BURBON ($31.49 / 750 ML) - $13.03↓, Active to De-Listed
• [D] BOONE COUNTY SMALL BATCH RYE WHISKEY ($29.49 / 750 ML) - $12.50↓, Active to De-Listed
• [A] HIGH WEST MANHATTAN BARREL FINISHED COCKTAIL RTD ($27.99 / 750 ML) - $12.00↓
• [A] HUDSON BABY BOURBON ($27.99 / 750 ML) - $12.00↓
• [D] HUDSON DO THE RYE THING ($27.99 / 750 ML) - $12.00↓, Active to De-Listed
• [D] HUDSON SINGLE BABY BOURBON BARREL ($27.99 / 750 ML) - $12.00↓, Special Order to De-Listed
• [D] YELLOW ROSE RYE WHISKEY ($27.49 / 750 ML) - $11.50↓, Active to De-Listed
• [D] JIM BEAM ORANGE ($25.99 / 1.75 Liter) - $11.00↓, Active to De-Listed
• [D] MAKERS MARK 46 WITH 2 COASTERS ($25.99 / 750 ML) - $11.00↓, Value Added Packs to De-Listed
• [D] MAKER'S MARK 46 WITH STOPPER ($25.99 / 750 ML) - $11.00↓, Value Added Packs to De-Listed
• [D] MAKERS MARK GIFT ($24.99 / 375 ML) - $10.35↓, Value Added Packs to De-Listed
• [D] SLAUGHTER HOUSE WHISKEY ($24.49 / 750 ML) - $10.20↓, Active to De-Listed
• [D] BOWMAN BROTHERS SMALL BATCH ($20.99 / 750 ML) - $9.00↓, Special Order to De-Listed
• [A] DASHFIRE BOURBON OLD FASHIONED COCKTAIL RTD ($20.99 / 750 ML) - $9.00↓
• [D] GENTLEMAN JACK GIFT ($20.99 / 750 ML) - $9.00↓, Value Added Packs to De-Listed
• [D] HOTEL TANGO BOURBON BOTTLED IN BOND ($20.99 / 750 ML) - $9.00↓, Special Order to De-Listed
• [D] NELSON'S GREEN BRIER TENNESSEE WHISKEY ($20.99 / 750 ML) - $9.00↓, Active to De-Listed
• [D] 2BAR STRAIGHT BOURBON WHISKEY 80 PROOF ($20.99 / 750 ML) - $8.76↓, Active to De-Listed
• [A] CLEVELAND UNDERGROUND BLACK CHERRY ($34.99 / 750 ML) - $8.00↓
• [A] CLEVELAND WHEAT PENNY BOURBON ($34.99 / 750 ML) - $8.00↓
• [D] MAKERS MARK WITH MUGS ($18.99 / 750 ML) - $8.00↓, Value Added Packs to De-Listed
• [D] MAKER'S MARK WITH ORNAMENT ($18.99 / 750 ML) - $8.00↓, Value Added Packs to De-Listed
• [D] CASK & CREW WALNUT TOFFEE ($19.99 / 750 ML) - $5.00↓, Active to De-Listed
• [A] CLEVELAND MAGIC RABBIT WHISKEY ($21.99 / 750 ML) - $5.00↓
• [D] JACK DANIELS HONEY & ICE MOLD ($19.99 / 750 ML) - $5.00↓, Value Added Packs to De-Listed
• [D] JACK DANIELS MUSIC CTN WITH SHOT GLASS ($19.99 / 750 ML) - $5.00↓, Value Added Packs to De-Listed
• [D] JACK DANIELS HISPANIC CTN WITH 2 ROCK GLASSES ($19.49 / 750 ML) - $4.50↓, Value Added Packs to De-Listed
• [D] JIM BEAM BLACK WITH COASTERS ($17.99 / 750 ML) - $4.00↓, Value Added Packs to De-Listed
• [D] WHISKEYSMITH CHOCOLATE FLAVORED WHISKEY ($17.99 / 750 ML) - $4.00↓, Active to De-Listed
• [D] CATDADDY SPICED MOONSHINE ($15.99 / 750 ML) - $3.96↓, Special Order to De-Listed
• [D] JIM BEAM GIFT ($15.49 / 750 ML) - $3.50↓, Value Added Packs to De-Listed
• [D] JIM BEAM PEACH WITH HIGHBALL GLASS ($15.49 / 750 ML) - $3.50↓, Value Added Packs to De-Listed
• [D] ROBERSON'S TENNESSEE MELLOMOON ($14.49 / 750 ML) - $3.42↓, Active to De-Listed
• [A] CLEVELAND BRIDGE AND MAIN AMERICAN WHEAT ($24.99 / 750 ML) - $3.00↓
• [D] SENATORS CLUB ($11.99 / 1.75 Liter) - $3.00↓, Active to De-Listed
• [A] WESTERN RESERVE SMALL BATCH BOURBON ($36.99 / 750 ML) - $3.00↓
• [D] HOOTERS SPIRITS AMERICAN STRAIGHT WHISKEY ($12.99 / 1 Liter) - $2.84↓, Special Order to De-Listed
• [D] HOOTERS SPIRITS HEAT CINNAMON WHISKEY ($11.49 / 1 Liter) - $2.73↓, Special Order to De-Listed
• [A] QUALITY HOUSE ($10.49 / 1 Liter) - $2.50↓
• [A] CLYDE MAYS ALABAMA STYLE WHISKEY 85P ($32.99 / 750 ML) - $2.00↓
• [A] CLYDE MAYS STRAIGHT BOURBON 92P ($34.99 / 750 ML) - $2.00↓
• [A] HIGH WEST BOURBON ($37.99 / 750 ML) - $2.00↓
• [A] HIGH WEST DOUBLE RYE ($37.99 / 750 ML) - $2.00↓
• [A] OLE SMOKY COOKIE DOUGH WHISKEY ($17.99 / 750 ML) - $2.00↓
• [A] OLE SMOKY PEANUT BUTTER WHISKEY ($17.99 / 750 ML) - $2.00↓
• [A] OLE SMOKY SALTY CARAMEL WHISKEY ($17.99 / 750 ML) - $2.00↓
• [S] GOODWOOD BOURBON FINISHED IN WALNUT BROWN BARRELS ($67.99 / 750 ML) - $0.41↓
• [A] GOODWOOD HONEY ALE FINISHED BOURBON ($67.99 / 750 ML) - $0.41↓
• [A] GOODWOOD RYE ($67.99 / 750 ML) - $0.41↓
• [A] GOODWOOD STOUT FINISHED BOURBON ($67.99 / 750 ML) - $0.41↓
• Price increases
• [S] COLONEL E.H. TAYLOR STRAIGHT RYE ($69.99 / 750 ML) - $28.00↑, De-Listed to Special Order
• Changed products
• [D] JIM BEAM ORANGE PET ($34.99 / 1.75 Liter) - Active to De-Listed
• [D] KNOB CREEK RYE CASK STRENGTH 2019 ($69.99 / 750 ML) - Active to De-Listed
• [D] REBEL 100 PROOF ($2.00 / 50 ML) - Active to De-Listed
• [S] BROWN SUGAR BOURBON ($17.99 / 750 ML) - $7.00↑, De-Listed to Special Order

Brandy

• New Products
• [A] MEUKOW VS COGNAC ($7.99 / 200 ML)
• [A] PAUL MASSON VS TRAVELER ($9.99 / 750 ML)
• [A] R JELINEK SLIVOVITZ 5 YEAR ($23.95 / 700 ML)
• [A] TAKOVO PRIRODNA PREPECENICA PLUM BRANDY ($29.73 / 1 Liter)
• Price decreases
• [D] BRANSON XO COGNAC ($149.99 / 750 ML) - $100.01↓, Special Order to De-Listed
• [D] HENNESSY XO ICE EXPERIENC ($149.49 / 750 ML) - $99.50↓, Value Added Packs to De-Listed
• [D] BRANSON VSOP COGNAC ($41.99 / 750 ML) - $28.00↓, Special Order to De-Listed
• [D] HENNESSY VSOP PRIVILEGE MANHATTAN VAP ($38.49 / 750 ML) - $25.50↓
• [D] BRANSON VSOP ROYAL COGNAC ($35.99 / 750 ML) - $24.00↓, Special Order to De-Listed
• [D] NONINO MERLOT ($34.49 / 750 ML) - $22.50↓, Active to De-Listed
• [D] REMY MARTIN VSOP HERITAGE EDITION ($34.99 / 750 ML) - $15.00↓, Special Order to De-Listed
• [D] COPPER & KINGS CRAFT BRANDY ($24.49 / 750 ML) - $10.50↓, Active to De-Listed
• [D] FLORES ZUTA OSA ($21.99 / 750 ML) - $9.19↓, Active to De-Listed
• [D] MASION GAUTIER COGNAC VS ($19.99 / 750 ML) - $8.00↓, Active to De-Listed
• [S] CONCIERE BRANDY ($13.69 / 1 Liter) - $1.21↓

Canadian Whiskey

• New Products
• [A] CROWN ROYAL GOLDEN APPLE 23YR ($249.99 / 750 ML)
• Price decreases
• [A] 18 YEAR CARIBBEAN CASK RYE WHISKEY ($124.99 / 750 ML) - $50.00↓
• [D] REVEL STOKE ROASTED PINEAPPLE ($11.49 / 750 ML) - $2.50↓, Special Order to De-Listed
• [A] CROWN ROYAL PEACH ($26.99 / 750 ML) - $1.00↓
• [A] BLACK VELVET ($4.99 / 375 ML) - $0.50↓
• Changed products
• [D] MCMASTERS CANADIAN ($7.49 / 750 ML) - Active to De-Listed

Cordial

• New Products
• [A] CROOKED FINGER BASIL LIQUEUR ($34.69 / 750 ML)
• [A] FIREBALL 100ML 6 PACK CARRIER ($10.99 / 600 ML)
• [A] FIREBALL 20 PACK WINDOW BOX ($15.99 / 600 ML)
• Price decreases
• [D] DESTILLARE ORANGE CURACAO ($20.99 / 750 ML) - $9.00↓, Special Order to De-Listed
• [D] RIGA BLACK BALSAM ($20.99 / 750 ML) - $9.00↓, Active to De-Listed
• [D] VECCHIO AMARO DEL CAPO ($20.99 / 750 ML) - $9.00↓, Special Order to De-Listed
• [A] JAGERMEISTER ($39.99 / 1.75 Liter) - $8.50↓
• [D] JAGERMEISTER SUSTAINABLE MUG VAP ($19.49 / 750 ML) - $4.50↓, Value Added Packs to De-Listed
• [D] MOLINARI EXTRA ($19.49 / 750 ML) - $4.50↓, Special Order to De-Listed
• [D] AMARO ALTA VERDE ($16.99 / 750 ML) - $4.00↓, Active to De-Listed
• [D] IICHIKO SILHOUETTE SHOCHU ($15.99 / 750 ML) - $4.00↓, Special Order to De-Listed
• [D] ST ELDER BLOOD ORANGE LIQUEUR ($15.99 / 750 ML) - $4.00↓, Special Order to De-Listed
• [D] WEST 32 RESERVE SOJU ($15.99 / 750 ML) - $4.00↓, Active to De-Listed
• [D] DRAMBUIE ($15.49 / 375 ML) - $3.50↓, Active to De-Listed
• [D] PARAMOUNT PEPPERMINT ($14.49 / 1.75 Liter) - $3.50↓, Active to De-Listed
• [S] CONCIERE AMARETTO ($7.49 / 1 Liter) - $3.42↓
• [D] CONCIERE COFFEE LIQUEUR ($8.99 / 1 Liter) - $1.92↓, Special Order to De-Listed
• Changed products
• [D] BOLS BLUE CURACAO ($8.65 / 750 ML) - Active to De-Listed
• [S] MARTINI & ROSSI BITTER ($19.99 / 750 ML) - De-Listed to Special Order

Gin

• New Products
• [A] A.M. SCOTT DISTILLERY GIN ($24.99 / 750 ML)
• [A] BOMBAY PREMIUM CRU ($34.99 / 700 ML)
• [S] BRECKENRIDGE GIN ($18.64 / 1 Liter)
• [A] HENDRICK'S FLORA ADORA GIN ($40.99 / 750 ML)
• [A] LAKE ERIE 5 BOTANICAL GIN ($50.14 / 750 ML)
• [V] MALFY ROSA COPA GLASS GIFT SET ($28.99 / 750 ML)
• Price decreases
• [D] THE BOTANIST ($27.99 / 750 ML) - $12.00↓
• [D] MONKEY 47 GIN W 2 CUPS ($25.99 / 375 ML) - $11.00↓, Value Added Packs to De-Listed
• [D] LONEWOLF CLOUDY LEMON GIN ($22.49 / 750 ML) - $9.50↓, Special Order to De-Listed
• [D] LONEWOLF GIN ($22.49 / 750 ML) - $9.00↓, Special Order to De-Listed
• [D] JUNIPERO ($22.49 / 750 ML) - $8.97↓, Special Order to De-Listed
• [A] WESTERN RESERVE ORGANIC PREMIUM GIN ($24.99 / 750 ML) - $4.96↓
• [D] BIERCEE PEKET DE HOUYEU ($17.49 / 750 ML) - $4.00↓, Special Order to De-Listed
• [A] MALFY GIN CON ARANCIA ($28.99 / 750 ML) - $3.00↓
• [A] MALFY GIN CON LIMONE ($28.99 / 750 ML) - $3.00↓
• [V] Malfy Gin Con Limone With 2 Glasses ($28.99 / 750 ML) - $3.00↓
• [A] MALFY ORIGINALE GIN ($28.99 / 750 ML) - $3.00↓
• [A] MALFY ROSA GIN ($28.99 / 750 ML) - $3.00↓
• [D] RIVES 1880 ($13.99 / 750 ML) - $3.00↓, Active to De-Listed
• [A] GILBEYS GIN ($9.49 / 1 Liter) - $2.00↓
• [D] HOOTERS SPIRITS GIN ($8.49 / 1 Liter) - $1.72↓, Special Order to De-Listed
• [S] PRAIRIE GIN ($17.99 / 750 ML) - $1.50↓, De-Listed to Special Order
• Changed products
• [D] INDOGGO GIN ($0.99 / 50 ML) - Active to De-Listed
• [D] SEAGRAMS EXTRA DRY GIN ($1.00 / 50 ML) - Active to De-Listed

Irish Whisky

• New Products
• [A] GLENDALOUGH 7YR MIZUNARA ($99.99 / 750 ML)
• [A] GLENDALOUGH DOUBLE BARREL IRISH WHISKEY ($29.99 / 750 ML)
• [A] GLENDALOUGH POT STILL IRISH WHISKEY ($49.99 / 750 ML)
• [A] SAILOR'S HOME HORIZON ($64.99 / 750 ML)
• Price decreases
• [D] REDBREAST SMALL BATCH ($62.49 / 750 ML) - $41.50↓, Special Order to De-Listed
• [D] TYRCONNELL 10 YEAR MADEIRA CASK ($32.99 / 750 ML) - $22.00↓, Active to De-Listed
• [D] TYRCONNELL 10 YEAR PORT CASK ($32.99 / 750 ML) - $22.00↓, Active to De-Listed
• [D] IRISH AMERICAN ($22.49 / 750 ML) - $9.51↓, Special Order to De-Listed
• Changed products
• [S] JAMESON 18 YEAR ($169.99 / 750 ML) - Active to Special Order
• [S] JAMESON MINI BAR ($3.99 / 600 ML) - Active to Special Order

Rum

• New Products
• [A] BACARDI MANGO CHILE ($13.99 / 750 ML)
• [S] CALYPSO SPICED RUM ($8.51 / 1 Liter)
• [A] CHAIRMAN'S RESERVE 1931 ($99.99 / 750 ML)
• [A] RHUM J M VSOP ($57.99 / 700 ML)
• [A] RHUM J.M. GOLD ($39.99 / 700 ML)
• Price decreases
• [D] HAMPDEN ESTATE OVERPROOF ($44.49 / 750 ML) - $29.50↓, Active to De-Listed
• [D] ANGOSTURA 1919 RUM ($26.99 / 750 ML) - $11.00↓, Active to De-Listed
• [D] AVUA CACHACA PRATA ($22.49 / 750 ML) - $9.50↓, Active to De-Listed
• [D] RUM BAR JAMAICAN GOLD RUM ($20.49 / 1 Liter) - $8.68↓, Active to De-Listed
• [D] FIVE HUNDRED CUTS BOTANICAL RUM ($18.49 / 750 ML) - $7.50↓, Special Order to De-Listed
• [A] TIKI LOVERS DARK RUM ($19.99 / 750 ML) - $5.00↓
• [S] CONCIERE GOLD RUM ($8.69 / 1 Liter) - $4.23↓
• [D] ANGOSTURA 5 YEAR RUM ($15.99 / 750 ML) - $4.00↓, Active to De-Listed
• [D] BAYOU RUM SILVER ($15.99 / 750 ML) - $4.00↓, Special Order to De-Listed
• [A] SALTWATER WOODY REAL GRAPEFRUIT ($14.49 / 750 ML) - $3.49↓
• [D] GOSLINGS GOLD SEAL ($13.99 / 750 ML) - $3.00↓, Special Order to De-Listed
• [D] SAO PAULO CACHACA ($10.49 / 1 Liter) - $2.53↓, Special Order to De-Listed
• [D] CONCIERE SPICED RUM ($10.49 / 1 Liter) - $2.43↓, Special Order to De-Listed
• [D] CRUZAN CITRUS RUM ($7.99 / 750 ML) - $2.00↓, Special Order to De-Listed
• [D] HOOTERS SPIRITS DARK RUM ($9.49 / 1 Liter) - $1.81↓, Special Order to De-Listed
• [D] HOOTERS SPIRITS LIGHT RUM ($9.49 / 1 Liter) - $1.81↓, Special Order to De-Listed
• [A] WESTERN RESERVE DISTILLERS PREMIUM RUM ($24.99 / 750 ML) - $1.00↓
• Price increases
• [S] CRUZAN SINGLE BARREL ($22.99 / 750 ML) - $4.60↑, De-Listed to Special Order
• Changed products
• [D] CAPTAIN MORGAN SLICED APPLE RUM ($1.00 / 50 ML) - Special Order to De-Listed

Scotch

• New Products
• [A] BUCHANANS PINEAPPLE ($34.99 / 750 ML)
• [A] LOCH LOMOND ORIGINAL SINGLE MALT SCOTCH WHISKY ($29.99 / 750 ML)
• Price decreases
• [S] MACALLAN 30 ($2,500.01 / 750 ML) - $2,499.96↓
• [D] TALISKER 30 YEAR OLD SINGLE MALT SCOTCH WHISKY ($499.99 / 750 ML) - $500.00↓, Special Order to De-Listed
• [D] LAPHROAIG 25 YEAR 2015 ($449.99 / 750 ML) - $300.00↓, Special Order to De-Listed
• [D] LAPHROAIG 25 YEAR 2019 ($449.99 / 750 ML) - $300.00↓, Special Order to De-Listed
• [D] ARDBEG 22 YEAR OLD ($274.99 / 750 ML) - $275.00↓, Special Order to De-Listed
• [D] HAKUSHU 18 YEAR ($359.99 / 750 ML) - $240.00↓, Special Order to De-Listed
• [D] GLENFIDDICH GRAND CRU 23 YO ($185.99 / 750 ML) - $124.00↓, Special Order to De-Listed
• [D] ABERLOUR 18 YEAR FIRST FILL SHERRY ($179.99 / 750 ML) - $120.00↓
• [D] CARDHU 16 YEAR OLD SINGLE MALT SCOTCH WHISKY ($107.99 / 750 ML) - $72.00↓, Active to De-Listed
• [D] GLENMORANGIE TALE OF WINTER GB ($59.99 / 750 ML) - $40.00↓, Active to De-Listed
• [D] PAUL JOHN CHRISTMAS 2020 EDITION ($50.99 / 750 ML) - $34.00↓, Special Order to De-Listed
• [D] HIGHLAND PARK VALKYRIE ($47.99 / 750 ML) - $32.00↓, Active to De-Listed
• [D] SIGNATORY 2008 MORTLACH UNCHILLFILTERED ($44.99 / 750 ML) - $30.00↓, Special Order to De-Listed
• [D] EDRADOUR 10 YEAR SINGLE MALT SCOTCH ($41.99 / 750 ML) - $28.00↓, Special Order to De-Listed
• [A] GLENFIDDICH INDIA PALE ALE CASK ($31.99 / 750 ML) - $21.00↓
• [D] AUCHENTOSHAN AMERICAN OAK ($34.99 / 750 ML) - $15.00↓, Active to De-Listed
• [D] SPEYBURN COMPANION CASK ($31.49 / 750 ML) - $13.49↓, Special Order to De-Listed
• [D] SHINJU ($26.99 / 750 ML) - $11.07↓, Special Order to De-Listed
• [D] GLENMORANGIE 10 YEAR OLD GIRAFFE TIN ($30.49 / 750 ML) - $9.50↓, Value Added Packs to De-Listed
• [S] CONCIERE SCOTCH ($11.79 / 1 Liter) - $6.12↓
• [A] ARDBEG 10 ($59.99 / 750 ML) - $5.00↓
• Price increases
• [A] DEWARS 8 CARIBBEAN SMOOTH ($24.99 / 750 ML) - $6.50↑, De-Listed to Active
• Changed products
• [S] GLENLIVET XXV ($449.97 / 750 ML) - Active to Special Order

Tequila

• New Products
• [S] 818 EIGHT RESERVE ANEJO ($200.00 / 750 ML)
• [A] ASOMBROSO LA ROSA REPOSADO TEQUILA ($59.99 / 750 ML)
• [A] CAZADORES 100 YEAR ANNIVERSARY ($39.99 / 750 ML)
• [A] CENOTE ANEJO ($54.99 / 750 ML)
• [A] CENOTE REPOSADO ($49.99 / 750 ML)
• [A] CODIGO 1530 14 YEAR EXTRA ANEJO ($6,574.83 / 750 ML)
• [A] CODIGO 1530 TEQUILA ANEJO RARE HARE PLAYBOY BLACK ($1,687.83 / 1 Liter)
• [A] DOS PRIMOS ANEJO ($54.99 / 750 ML)
• [S] EL TEQUILENO BLANCO ($23.95 / 750 ML)
• [A] HERRADURA ULTRA ($32.99 / 375 ML)
• [A] KARRIKIN ANEJO BLAZE ($49.99 / 750 ML)
• [A] KARRIKIN BLAZE REPOSADO ($34.99 / 750 ML)
• [A] LAKE ERIE BLANCO AGAVE SPIRITS ($51.54 / 750 ML)
• [A] LAKE ERIE EL AGAVE SILVER ($51.54 / 750 ML)
• [A] LALO TEQUILA BLANCO ($49.99 / 750 ML)
• [A] LUNAZUL REPOSADO ($25.63 / 375 ML)
• [A] MANGO SHOTTA ($19.99 / 750 ML)
• [A] MARGARITAVILLE SILVER TEQUILA 10 PACK ($9.99 / 600 ML)
• [A] MILAGRO MARGARITA RTD ($16.99 / 375 ML)
• [A] PIEDRA AZUL BLANCO ($19.99 / 750 ML)
• [A] SIETE LEGUAS D'ANTANO EXTRA ANEJO ($299.99 / 750 ML)
• [A] TEREMANA BLANCO TEQUILA ($36.99 / 1 Liter)
• Price decreases
• [D] CINCORO ANEJO TEQUILA ($239.99 / 1.75 Liter) - $160.00↓, Active to De-Listed
• [D] EL MAYOR EXTRA ANEJO RUM CASK TEQUILA ($77.99 / 750 ML) - $52.00↓, Special Order to De-Listed
• [D] DEL MAGUEY CHICHICAPA ($44.99 / 750 ML) - $30.00↓, Special Order to De-Listed
• [D] DEL MAGUEY MINERO ($44.99 / 750 ML) - $30.00↓, Special Order to De-Listed
• [D] HERRADURA REPOSADO BARREL ($35.99 / 750 ML) - $24.00↓, Special Order to De-Listed
• [D] PATRON SILVER SPEC ($35.99 / 1 Liter) - $24.00↓, Active to De-Listed
• [A] TEQUILA TROMBA ANJEO ($35.99 / 750 ML) - $24.00↓
• [D] LA ADELITA REPOSADO TEQUILA ($31.99 / 750 ML) - $21.00↓, Active to De-Listed
• [D] PATRON SILVER WINDOW PACK ($34.49 / 750 ML) - $14.50↓, Active to De-Listed
• [D] PATRON SILVER HERITAGE TIN ($33.99 / 750 ML) - $14.00↓, Active to De-Listed
• [D] EL COBRE ($31.49 / 750 ML) - $13.50↓, Active to De-Listed
• [D] LA ADELITA BLANCO ($31.49 / 750 ML) - $13.50↓, Active to De-Listed
• [D] CABEZA TEQUILA ($30.99 / 1 Liter) - $13.14↓, Special Order to De-Listed
• [D] IXA SILVER ($30.49 / 1 Liter) - $12.86↓, Special Order to De-Listed
• [A] ASTRAL REPOSADO ($27.99 / 750 ML) - $12.00↓
• [D] SAN DIMAS MEZCAL ($27.99 / 750 ML) - $12.00↓, Active to De-Listed
• [D] TEQUILA TROMBA REPOSADO ($27.99 / 750 ML) - $12.00↓, Active to De-Listed
• [D] JAJA BLANCO TEQUILA ($24.49 / 750 ML) - $10.50↓, Special Order to De-Listed
• [D] TEQUILA TROMBA BLANCO ($24.49 / 750 ML) - $10.50↓, Active to De-Listed
• [A] SUAVECITO EXTRA ANEJO ($139.99 / 750 ML) - $10.00↓
• [D] TALERO TEQUILA SILVER ($23.99 / 750 ML) - $9.86↓, Active to De-Listed
• [D] TRES AGAVES BLANCO GIFT ($20.49 / 750 ML) - $8.50↓, Value Added Packs to De-Listed
• [D] HORNITOS REPOSADO W/2 SHOT GLASSES ($18.49 / 750 ML) - $7.50↓, Value Added Packs to De-Listed
• [A] WESTERN RESERVE ORGANIC ANEJO ($39.99 / 750 ML) - $6.00↓
• [A] WESTERN RESERVE ORGANIC REPOSADO ($29.99 / 750 ML) - $5.00↓
• [A] ASTRAL TEQUILA BLANCO ($24.99 / 750 ML) - $5.00↓
• [A] CODIGO 1530 BLANCO ($42.99 / 750 ML) - $5.00↓
• [A] CODIGO REPOSADO TEQUILA ($59.99 / 750 ML) - $5.00↓
• [A] WESTERN RESERVE ORGANIC BLANCO ($24.99 / 750 ML) - $4.96↓
• [A] CABO WABO BLANCO ($32.99 / 750 ML) - $4.00↓
• [A] CABO WABO REPOSADO ($37.99 / 750 ML) - $4.00↓
• [D] HOOTERS SPIRITS TEQUILA GOLD ($17.49 / 1 Liter) - $3.81↓, Special Order to De-Listed
• [D] HOOTERS SPIRITS TEQUILA SILVER ($17.49 / 1 Liter) - $3.81↓, Special Order to De-Listed
• [A] TILENO ESPADIN JOVEN MEZCAL ($49.99 / 750 ML) - $3.00↓

Vodka

See below

Company Name	Title	City
United States Secret Service	Criminal Investigator	Richmond
Blue Ridge Bank NA	EVP - Chief Human Resources Officer	Richmond
Early Autism Services	Behavior Technician	Richmond
Burger King/Carrols Corp	Restaurant Staff Team Member Crew - 974	Richmond
The Brass Tap - Craft Beer Bar & Restaurant	ServeBartender	Richmond
Mosaic Restaurant	Host/Hostess	Richmond
Crothall Healthcare	Off-Site Maintenance Supervisor	Richmond
St Jardins - Richmond, VA	Senior Dot Net Developer with Blazor	Richmond
PartnerMD	Patient Services Representative (PSR)/Medical Receptionist	Richmond
Federal Reserve Bank of Dallas	Software Engineer Java and Cloud Service/Angular Developer	Richmond
Saint Francis Home	Concierge- Assisted Living Facility	Richmond
Crothall Healthcare	HOUSEKEEPING OPERATIONS MANAGER, Days, Richmond, VA (1166428)	Richmond
United Language Group	Medical Site Credentialing Specialist	Richmond
Compass Behavioral Solutions	Child Behavior and Family Support Specialist	Richmond
Rapid Technologies	Sr. Java Program Analyst	Richmond
Comtec Information Systems	Systems Engineer	Richmond
Rapid Technologies	Java Program Analyst	Richmond
Candlewood Suites	Part Time Front Desk Receptionist	Richmond
Blue Ridge Bank NA	Immediate Openings EVP Chief Human Resources Officer Richmond	Richmond
East Providence	Director, Software Engineering	Richmond

Hey guys, here are some recent job openings in richmond. Feel free to comment here or send me a private message if you have any questions, I'm at the community's disposal! If you encounter any problems with any of these job openings please let me know that I will modify the table accordingly. Thanks!

The Richmond and Henrico County health districts are offering testing and free vaccines at the following locations:
Wednesday, April 5, 2 to 4 p.m., Henrico West Health Department, 8600 Dixon Powers Dr., Primary Moderna shots for age 6 months to 5 years old and bivalent boosters for age 6 years and older, Primary Pfizer shots for age 6 months and older, bivalent boosters for age 5 years and older, Novavax primary shots for age 12 and older, and boosters for age 18 and older, JYNNEOS shots and baby bivalent boosters. Walk-ups welcome but appointments encouraged.
Thursday, April 6, 2 to 4 p.m. - Cary Street, 400 E. Cary St., Primary Moderna shots for age 6 months to 5 years old and bivalent boosters for age 6 years and older, Primary Pfizer shots for age 6 months and older, bivalent boosters for age 5 years and older, Novavax primary shots for age 12 and older, and boosters for age 18 and older, JYNNEOS shots and baby bivalent boosters, walk-ups welcome but appointments encouraged.
Call the Richmond and Henrico COVID-19 Hotline at (804)205-3501 from 8 a.m. to 5 p.m. Monday through Friday for more information on testing sites, or go online at vax.rchd.com.
People can schedule an appointment online at vase.vdh.virginia.gov, vaccinate.virginia.gov or vax.rchd.com, or by calling (804)205-3501 or (877) VAX-IN-VA (1-877-829-4682).
The Virginia Department of Health also has a list of COVID- 19 testing locations around the state at www.vdh.virginia.gov/coronavirus/covid-19-testing/covid-19-testing-sites.

Poster: Zeb Love
Official Stream: Nugs.Net
Unofficial Stream: TBD
FANTASY GOOSE: Click Here
Tickets: Cash or Trade
Scheduled Start Time: 8:30pm CT (expect closer to 9PM CT)
Set 1 (8:42PM - 10:00PM)
Turbulence & The Night Rays (8)
Dr. Darkness (6)
The Whales (9)
AUATC ¹ (7)
Elizabeth (13)
Not Alone (7)
Arrow (27)
END SET
Set 2 (10:36PM - 11:41PM)
Hungersite (17)
Feel it Now (12)
Bob Don (6)
Drive (10)
Rosewood Heart (19)
END SET
Encore (11:44PM - 11:59PM)
Empress of Organos
Show Notes:
¹ Bon Iver
PETER-O-METER:
[ ] Flapping them jacks
[🎹] Tickling the ivories
[ ] Bouncing
[🎹 ] Keyboard Warrior
[ ] CLAV
[ ] 2-Guitar Goose
[ ] Time-traveling to the 80s
[ ] Backstage bananas
[ ] Rocking
[ ] Arpeggiating
[ ] Floating
[ ] Hip swangin'
[ ] "Are you freaking kidding me right now?"
[ ] Straight Bird'n
[ ] Channeling evil Goose
[ ] Flipping switches
[ ] Razzle dazzle shoulders
[ ] Entering inter-dimensional travel
[ ] Loving you guys
[ ] Summoning deep space aliens with a mating call
[👸🏻] Crowd Participating
[ ] Wondering whose first Goose show it is
SHOW INFO and SHENANIGANS
Happy Birthday u/username-checks--out!!!
Venue Info: Click Here
Weather: 70°F, with nasty storms
Check-In:
At the show: via Knoxville x2 via Memphis x3 via Detroit via Charlotte via Nashville via 12S At the show x 2 longest merch line on the planet sec 4 row x Sec 8 inside balcony via Pittsburgh front row of the balcony via Seneca, SC
Couch Tourin': NYC The Garden State Chicago, IL Marina, CA Mad Hatter Table, Bel Air, MD Seattle, WA North Central Mass. Asheville, NC Augusta, GA Albany, NY San Jose, CA Williamsburg, VA Newport Beach, CA South Korea 🇰🇷 White Mountains, NH Dayton, OH with doobies rolled! Knoxville, TN Rochester, NY x2 Columbus, OH Dirty South, NOLA Kona, HI Atlanta with kitty couch hogs Denver, CO the Zoo Baltimore Buffalo, NY Decorah, IA Granite State Milwaukee, WI x2 ATL Burbz Alameda, CA St. Paul, MN Hudson Valley, NY HTX Frederick, MD Camping on the beach in Malibu, CA Winston-Salem, NC SyraGoose, NY x2 Bay Area, CA Albuquerque, NM Cleveland, OH CT Midlothian, Virginia Mt. Shasta, CA Dab City, VT Trenton, NJ SSI, GA Indiana Fredericksburg, TX 603 NH some backroad in TexasIndianapolis x2 Corning NY Richmond, VA x2 Fairfield CT Landaff, NH Arlington, VA Madison, WI x2 chicagooooooooooose Rochester, NY ATL Airport Frederick, Colorado Castle Rock, CO Lodi, NJ Norwich, CT

Poster: Max Wesoloski
Official Stream: goosestreams.com
Unofficial Stream:
FANTASY GOOSE: Click Here
Tickets: Cash or Trade
 
Scheduled Start Time: 8:30pm CT (Post title is INCORRECT. 8:30 Central, local Nashville time)
 
Set 1 ( 8:57 - 10:13 )

Atlas Dogs (6) > Atlas¹ (13)

Butterflies 🦋 (7)

Indian River (7) > Ryman Jam (10)

Everything Must Go 🔥 (11)

Rockdale (19)

END SET
 
Set 2 ( 10:47 - 12:00 )

Wysteria Lane (27) > The Way It Is² (9)

Creatures (13) > Pancakes (17)

White Lights (5)

 
END SHOW
 
Show Notes: ¹ The Wood Brothers ² Bruce Hornsby No encore was performed, they played right up to curfew.
 
PETER-O-METER:
[ ] Flapping them jacks
[ ] Tickling the ivories
[ ] Bouncing
[ ] Keyboard Warrior
[ ] CLAV
[ ] 2-Guitar Goose
[ ] Time-traveling to the 80s
[ ] Backstage bananas
[ ] Rocking
[ ] Arpeggiating
[ ] Floating
[ ] Hip swangin'
[ ] "Are you freaking kidding me right now?"
[ ] Straight Bird'n
[ ] Channeling evil Goose
[ ] Flipping switches
[ ] Razzle dazzle shoulders
[ ] Entering inter-dimensional travel
[❤️] Loving you guys
[ ] Summoning deep space aliens with a mating call
[ ] Crowd Participating
[ ] Wondering whose first Goose show it is
SHOW INFO and SHENANIGANS
Venue Info: Click Here
Weather: 70°F, Mostly Sunny
Check-In: At the show! via Detroit Hometown Throwdown (Trev Side) via Raleigh, NC via Boston via Wilkes-Barre The Balcony via Knoxville, TN via Toronto 🇨🇦 Section 1, Pete Side Balcony via Leoma, TN Section 4 Section 8 Middle Back Floor
Couch Tourin' Oshkosh, WI Columbus, OH Knoxville, TN Work 👎 Phoenix, AZ ATL Burbz Los Gatos, CA Augusta, GA EPTX My Body Is Ready, NH Marina, CA Frederick, MD Williamsburg, VA LA Redwood City, CA Denver, CO Seneca, SC Bel Air, MD Tulsa, OK North Central MA N'awlins, LA And also New Orleans, LA Rochester, NY Chester, PA Long Island, NY NYC Dayton, OH Rochester, NY San Antonio, TX HTX Surprise surprise: Rochester, NY Charlevoix, MI Bay Area, CA ATL Fennario Madison, WI Milwaukee, WI St. Paul, MN Lancaster, PA Grand Prairie, TX Phoenix, AZ Indianapolis, IN Elizabethton, TN Chattanooga, TN Stamford, CT Chicago, IL Buffalo, NY Washington, DC Landaff, NH Can you believe? Rochester, NY Weathersfield, VT Rochester, NY 🌊 Milwaukee, WI Denver, CO Albertville, AL Bethesda, MD Lodi, NJ Knoxville, TN Atlanta, GA Minneapolis, MN Denver, CO Henderson, KY Albuquerque, NM Jonesboro, AR Cleveland, OH Memphis, TN Fairfield, CT Washington, DC ATL San Diego, CA New Orleans, LA Boston, MA SyraGoose, NY Philadelphia, PA SSI, GA New Brunswick, NJ Chicago, IL Asheville, NC Somerville MA Hackensack, NJ Raleigh, NC Delaware Seattle, WA Baltimore, MD Norwich, CT Palestine 🇵🇸 Alameda, CA Midlothian, VA Raleigh, NC Cranford, NJ Ft. Myers, FL Stevens Point, WI Richmond, VA Rochester, NY, damn Trenton, NJ Castle Rock, CO Dallas, TX Albany, NY Dallas, TX Mont Vernon, NH Atoka, OK Albany, NY Rochester, NY, because of course Kona, HI Conneaut Lake, PA Seattle, WA Westchester, NY Green Bay, WI Athens, OH Albany, NY KCMO Fredericksburg, TX Buffalo, NY Boonton, NJ

Listed below are tournaments to get involved in

​
Note: If you'd like to advertise for your unsanctioned tournament, please reply to this post and I will approve it if applicable.
​

This post was last updated 3/29/2023

​

USA Flag tournaments:

Las Vegas Open

• April 15 - April 16, 2023
• Henderson, NV
• Open to all participants

2023 National Championships

• May 26 - May 28 2023
• Arlington, TX
• Open to all participants

New York Open

• July 15 - July 16, 2023
• New York City, NY
• Open to all participants

Cedar Point Open

• August 19 - August 20, 2023
• Sandusky, OH
• Open to all participants

San Diego Open

• September 2 - September 3, 2023
• San Diego, CA
• Open to all participants

Orlando Open

• September 23 - September 24, 2023
• Orlando, FL
• Open to all participants

USA vs Mexico Invitational

• October 7 - October 8, 2023
• McAllen, TX
• Invite-only international tournament

Phoenix Open

• December 9 - December 10, 2023
• Phoenix, AZ
• Open to all participants

2024 World Championships

• January 11 - January 14, 2024
• Tampa, FL

Un-affiliated, Sanctioned USA Flag tournaments:

Sunshine Bowl

• Organized by: Special Olympics Florida
• Age Groups: Adult Mens, Adult Womens, Adult Coed, High School
• April 22 - April 23, 2023
• Tampa, FL

Battle at the Bullitt 5v5

• Organized by: The Bullitt Experience
• Age Groups: Youth 6U - 18U, High School Girls 7v7
• April 30, 2023
• Rowlett, TX

Richmond East Coast Nationals

• Organized by: DMVFFL
• Age Groups: Youth 6U - 18U, Adult Mens, Adult Womens, Adult Coed
• May 5 - May 7, 2023
• Richmond, VA

The Shruumz Drip Trouney

• Organized by: Dipz & Drip Tourneys
• Age Groups: Youth 6U - 18U, Adult Mens, Adult Womens, Adult Coed
• July 22 - July 23, 2023
• Austin, TX

Lynn Lewis Foundation 16th Annual Invitational

• Organized by: Lynn Lewis Foundation
• Age Groups: High School Girls 7v7, Adult Womens
• October 13 - October 15, 2023
• Mesa, AZ

Other Tournaments:

FlagFootballX

• Notes: Monthly tournament held in Arlington, TX with seeding games held in Irving, TX on Saturday and playoffs held in AT&T Stadium on Sunday
• Tournament information: https://www.zortssports.com/tournament/app/10612
• Age Groups: All ages, Men's, Women's
• April 15 - April 16, 2023
• Arlington, TX

Predict, Discuss and Follow the Weekend's Events

Use these discussion threads to talk about matchups, share predictions, find stream info, react to results and more. You can also chat live in our discord channel. Feel free to discuss any event, not just the featured events!

Easterns

April 1-2 in partly cloudy Little River, SC
Livestreaming Schedule

Date	Local Time	UTC Time	Div	Matchup	Watch
Sat 4/1	9:00am ET	1:00pm UTC	Men	#15 Tufts vs #22 Georgia	Ultiworld ($)
Sat 4/1	10:45am ET	2:45pm UTC	Men	#7 Oregon vs #14 Brown	Ultiworld ($)
Sat 4/1	12:30pm ET	4:30pm UTC	Men	#11 Minnesota vs #18 Northeastern	Ultiworld ($)
Sat 4/1	2:15pm ET	6:15pm UTC	Men	#4 Vermont vs #8 Cal Poly-SLO	Ultiworld ($)
Sat 4/1	4:00pm ET	8:00pm UTC	Men	#1 Massachusetts vs #12 Pittsburgh	Ultiworld ($)
Sun 4/2	9:00am ET	1:00pm UTC	Men	Quarterfinal	Ultiworld ($)
Sun 4/2	11:00am ET	3:00pm UTC	Men	Semifinal	Ultiworld ($)
Sun 4/2	1:00pm ET	5:00pm UTC	Men	Final	Ultiworld ($)

Easterns is US Eastern time. Viewing requires a Full ($12.99/mo) or Plus ($19.99/mo) subscription. Games WILL have commentary. Schedule subject to change but won't be updated here. If the links don't work, try here.
Men's Pools – Schedule and Results

Pool A	Pool B	Pool C	Pool D
#1 Massachusetts	#2 North Carolina	#4 Vermont	#7 Oregon
#12 Pittsburgh	#11 Minnesota	#8 Cal Poly-SLO	#13 Carleton
#24 NC State	#18 Northeastern	#15 Tufts	#14 Brown
#21 California	#20 Ohio State	#22 Georgia	#17 Michigan
Auburn	UNC-Wilmington	Wisconsin	#25 South Carolina

Follow: Preview, Podcast, @EasternsTD, Easterns Facebook, @Ultiworld, @UltiworldLive

Northwest Challenge

April 1-2 in rainy Seattle, WA
Men's Pools – Schedule and Results

Pool A	Pool B	Pool C	Pool D
#19 British Columbia	#16 Washington	Utah State	#23 Oregon State
#12 D-III Whitman	Utah	Western Washington	Victoria
Dartmouth	Washington State	Gonzaga	Chico State

Women's Division – Schedule and Results
The main women's division was last weekend, however, it looks like there will be at least one game between #5 Portland and #7 Whitman this weekend (D-III rankings), as part of the Tier 2 division.
Follow: Podcast, @DiscNW, @Ultiworld, @UltiworldLive

Huck Finn

April 1-2 in partly cloudy O'Fallon, IL (near St Louis)
Men's Pools – Schedule and Results

Pool A (Tier 1)	Pool B (Tier 1)	Pool C (Tier 2)	Pool D (Tier 2)	Pool E (Tier 3)	Pool F (Tier 3)
Washington-St Louis	Iowa State	Wisconsin-Milwaukee	#10 D-III St Olaf	St Louis	Marquette
Emory	Missouri	#6 D-III Grinnell	Illinois	Boston University	Georgia State
Cincinnati	Purdue	Chicago	Kentucky	Arizona State	Illinois State
Notre Dame	Alabama	Florida State	#9 D-III Missouri S&T	DePaul	Central Michigan
Vanderbilt	Indiana	#8 D-III John Brown	Michigan State

All teams can reach the championship bracket, but more spots are allocated to teams in higher tiers.
Follow: Tournament Site, @HuckFinnTDs, @Ultiworld, @UltiworldLive

East Coast Scrimmage Weekend

April 1 in rainy Ardmore, PA (near Philadelphia)
Women's Pool – Schedule and Results

Pool A
#1 North Carolina
#2 Vermont
#5 Tufts
#15 Yale

Follow: @UNC_Pleiades, @AFDCJuniors, @Ultiworld, @UltiworldLive

B-Team Brodown

April 1-2 in partly cloudy Pittsburgh, PA
Men's Pools – Schedule and Results

Pool A	Pool B	Pool C	Pool D
Pittsburgh-B	Penn State-B	#21 D-III Franciscan	#23 D-IIII Messiah
Ohio	Lehigh-B	Michigan-B	Ohio State-B
#18 D-III Rochester	Carnegie Mellon-B	Shippensburg	Case Western-B
SUNY-Fredonia	Ave Maria	Dayton-B	SUNY-Buffalo-B

Follow: @PghUltimate, @PittUltimateM_B, @Ultiworld, @UltiworldLive

Atlantic Coast Open

April 1-2 in partly cloudy Axton, VA
Women's Pools – Schedule and Results

Pool A
Cornell
Liberty
George Washington
George Mason
Cornell-B

Men's Pools – Schedule and Results

Pool A	Pool B	Pool C	Pool D	Dev Round Robin
Penn State	Duke	Rutgers	Cornell	Maryland-B
#3 D-III Richmond	Virginia Tech	Lehigh	Georgetown	South Carolina-B
#5 D-III Navy	Temple	Connecticut	Liberty	Virginia Tech-B
Johns Hopkins	MIT	VCU	East Carolina	Cornell-B
George Mason	American	Charlotte YCC		Georgetown-B
				George Washington-B
				American-B

Follow: Tournament Site, @OakCreekUlti, @Ultiworld, @UltiworldLive
Top 25 Rankings from Ultiworld Top 25, but not yet updated for this week.

CAREER EMPLOYEES! Tired of seeing all these jobs go to the street? Your chance to join the gravy train ranks is almost gone! Apply yourself, you can do it! MSS Coordinator varies by District.
New record on MM-7 mechanic jobs. USPS really out to fuck the people that are already career, they're not even trying to hide it. Also, I forgot how to count. Moved ahead a month oops - take two!
​
Good afternoon. Brief listing of CAREER JOBS pulled from usps.com/careers/ for your convenience.
Some jobs may be part-time regular however all listed jobs should qualify for federal benefits from day one. To save text I have only listed the location and date of posting for each. Use the posting number for your search term. LC and MM are entry-level Maintenance. Here is a testimonial from a recent convert, prima1981.
​
NOTE: USPS NEVER charges a fee for entrance exams. If payment is requested during the application process, walk the fuck away, go to usps.com/careers/ and APPLY THERE. We even has a video walkthrough prepared.
​
Laborer Custodial:
CANAL WINCHESTER OH NC11298992 03/23/2023
GRANVILLE OH NC11298999 03/23/2023
CHARLEVOIX MI NC11297550 03/22/2023
SAN FRANCISCO CA NC11272282 03/16/2023
REDMOND WA NC11290022 03/15/2023
KETCHUM ID NC11302140 03/25/2023
WHITE PLAINS NY NC11301053 03/25/2023
BRATTLEBORO VT NC11300914 03/25/2023
DICKINSON ND NC11300841 03/24/2023
BISMARCK ND NC11300837 03/24/2023
BISMARCK ND NC11300831 03/24/2023
CROOKSTON MN NC11300673 03/24/2023
WHITE RIVER JUNCTION VT NC11300224 03/24/2023
FENTON MO NC11299177 03/24/2023
BOSTON MA NC11299139 03/24/2023
PENDLETON OR NC11299123 03/24/2023
GRAY GA NC11297961 03/23/2023
LAGRANGE GA NC11297953 03/23/2023
JESUP GA NC11297950 03/23/2023
KINGSLAND GA NC11297774 03/23/2023
NORTH READING MA NC11297767 03/23/2023
HICKORY NC NC11297724 03/23/2023
PETALUMA CA NC11296097 03/22/2023
SAN FRANCISCO CA NC11285816 03/20/2023
LEESBURG VA NC11294817 03/19/2023
TRAVERSE CITY MI NC11293101 03/18/2023
WHITE PLAINS NY NC11301206 03/25/2023
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Maintenance Mechanic:
SHREWSBURY MA NC11299180 03/24/2023
SAN JOSE CA NC11289187 03/21/2023
SAINT PAUL MN NC11299102 03/23/2023
SAINT PAUL MN NC11298964 03/23/2023
RICHMOND CA NC11302501 03/25/2023
PHOENIX AZ NC11294808 03/20/2023
PHILADELPHIA PA NC11302228 03/25/2023
OAKLAND CA NC11299110 03/23/2023
MERRIFIELD VA NC11294815 03/19/2023
MEMPHIS TN NC11297952 03/23/2023
LOUISVILLE KY NC11288732 03/20/2023
JAMAICA NY NC11288847 03/25/2023
HARTFORD CT NC11300915 03/25/2023
WHITE PLAINS NY NC11301200 03/25/2023
RICHMOND CA NC11302407 03/25/2023
MEMPHIS TN NC11293083 03/18/2023
MELVILLE NY NC11288826 03/25/2023
LOUISVILLE KY NC11288711 03/20/2023
CHICAGO IL NC11292143 03/17/2023
AUGUSTA GA NC11292936 03/17/2023
PHILADELPHIA PA NC11302333 03/25/2023
PETALUMA CA NC11289177 03/21/2023
LOUISVILLE KY NC11288728 03/20/2023
CAROL STREAM IL NC11292109 03/17/2023
HISTORIC NEW CASTLE DE NC11299043 03/26/2023
WHITE PLAINS NY NC11301213 03/25/2023
WHITE PLAINS NY NC11301150 03/25/2023
RICHMOND CA NC11299029 03/23/2023
PHILADELPHIA PA NC11302325 03/25/2023
MACON GA NC11292871 03/17/2023
LOUISVILLE KY NC11301171 03/25/2023
LOUISVILLE KY NC11301158 03/25/2023
KEARNY NJ NC11296167 03/27/2023
DES MOINES IA NC11302145 03/25/2023
DALLAS TX NC11299590 03/24/2023
COPPELL TX NC11299592 03/24/2023
BELL GARDENS CA NC11287325 03/21/2023
FARMINGTON NM NC11294794 03/20/2023
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Special! Interesting Maintenance Jobs: (may be skills required)
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Maintenance Mechanic MPE:
CAPITOL HEIGHTS MD NC11297600 03/23/2023
MELVILLE NY NC11288829 03/25/2023
FARGO ND NC11302226 03/25/2023
DULLES VA NC11294816 03/19/2023
WEST FARGO ND NC11302193 03/25/2023
WAITE PARK MN NC11304276 03/26/2023
PHILADELPHIA PA NC11302284 03/25/2023
FARGO ND NC11302190 03/25/2023
BOSTON MA NC11296309 03/22/2023
PETALUMA CA NC11289175 03/21/2023
PORTLAND OR NC11301307 03/25/2023
NORTH READING MA NC11297723 03/23/2023
MINNEAPOLIS MN NC11302329 03/25/2023
MEMPHIS TN NC11293003 03/18/2023
LOUISVILLE KY NC11301303 03/25/2023
LOUISVILLE KY NC11288712 03/20/2023
DALLAS TX NC11299578 03/24/2023
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Building Equipment Mechanic:
HEIGHTS MD NC11290064 03/16/2023
MINNEAPOLIS MN NC11302244 03/25/2023
PHILADELPHIA PA NC11302230 03/25/2023
MINNEAPOLIS MN NC11302294 03/25/2023
SEATTLE WA NC11294603 03/18/2023
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Garage Assistant:
MCALLEN TX NC11291630 03/16/2023
AURORA IL NC11302233 03/25/2023
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General Clerk VMF:
MANCHESTER NH NC11299377 03/24/2023
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Electronic Technician:
NORTH READING MA NC11299182 03/24/2023
CHICAGO IL NC11292188 03/17/2023
DETROIT MI NC11300595 03/24/2023
LOUISVILLE KY NC11301165 03/25/2023
MEMPHIS TN NC11297768 03/23/2023
PHILADELPHIA PA NC11302246 03/25/2023
WHITE PLAINS NY NC11301212 03/25/2023
MEMPHIS TN NC11293110 03/18/2023
CAPITOL HEIGHTS MD NC11294867 03/19/2023
MANKATO MN NC11302194 03/25/2023
NORTH READING MA NC11297614 03/23/2023
BEMIDJI MN NC11300829 03/24/2023
COPPELL TX NC11299593 03/24/2023
LUBBOCK TX NC11294802 03/19/2023
PHILADELPHIA PA NC11302236 03/25/2023
WASHINGTON DC NC11297954 03/23/2023
WEST FARGO ND NC11302144 03/25/2023
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NON-Maintenance jerbs:
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SALES,SVCS/DISTRIBUTION ASSOC:
GLASGOW MT NC11296091 03/21/2023
MAPLE FALLS WA NC11296082 03/19/2023
FLORA VISTA NM NC11305346 03/28/2023
EASTSOUND WA NC11295971 03/20/2023
CULLEOKA TN NC11294523 03/18/2023
CORVALLIS MT NC11299118 03/24/2023
WYMORE NE NC11299107 03/23/2023
PALMYRA VA NC11299598 03/24/2023
FREELAND WA NC11301079 03/25/2023
BASSETT NE NC11294668 03/18/2023
SPRINGDALE WA NC11296087 03/20/2023
PERKINSTON MS NC11297989 03/23/2023
SELLS AZ NC11302414 03/25/2023
KENAI AK NC11300907 03/24/2023
ASPEN CO NC11297726 03/23/2023
ABERDEEN MS NC11297984 03/23/2023
BORGER TX NC11299103 03/24/2023
HONEY BROOK PA NC11296174 03/22/2023
DALLASTOWN PA NC11296576 03/22/2023
WATERLOO NE NC11298987 03/23/2023
VALDERS WI NC11301030 03/25/2023
SELLS AZ NC11302451 03/25/2023
RUTLAND MA NC11299516 03/24/2023
ROY WA NC11296081 03/20/2023
REEDLEY CA NC11296222 03/24/2023
QUILCENE WA NC11296078 03/20/2023
PIEDMONT OK NC11297962 03/23/2023
ORTING WA NC11297556 03/22/2023
ORLEANS MA NC11298202 03/23/2023
OLIVET MI NC11291746 03/17/2023
HILLS IA NC11299034 03/23/2023
ESSEX MA NC11296340 03/22/2023
DEXTER OR NC11296094 03/21/2023
COOL CA NC11300901 03/24/2023
CLARKSTON WA NC11295974 03/20/2023
BETHPAGE TN NC11294606 03/18/2023
SLIPPERY ROCK PA NC11296544 03/22/2023
CAVE JUNCTION OR NC11296085 03/21/2023
SAINT MATTHEWS SC NC11302467 03/26/2023
HICO TX NC11293402 03/18/2023
WILLARDS MD NC11298205 03/23/2023
WAIMANALO HI NC11294630 03/18/2023
LAKELAND MI NC11302798 03/26/2023
CARMEL VALLEY CA NC11298211 03/24/2023
HOWARD LAKE MN NC11302853 03/26/2023
GORDON NE NC11294636 03/18/2023
CASTROVILLE CA NC11297538 03/22/2023
DELTA JUNCTION AK NC11300799 03/24/2023
BLOOMING PRAIRIE MN NC11296095 03/20/2023
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City Carrier:
BROOMFIELD CO NC11275444 03/21/2023
ALBANY NY NC11305449 03/28/2023
APTOS CA NC11291514 03/24/2023
BARRINGTON IL NC11294396 03/25/2023
CAMP HILL PA NC11296490 03/22/2023
EAST PALO ALTO CA NC11292056 03/24/2023
GLENSHAW PA NC11296496 03/22/2023
LAKE FOREST IL NC11294505 03/28/2023
LOS ALTOS CA NC11291594 03/24/2023
MC LEAN VA NC11288929 03/15/2023
MORGAN HILL CA NC11292053 03/24/2023
MOUNT PROSPECT IL NC11293521 03/26/2023
MOUNTAIN VIEW CA NC11292059 03/24/2023
MUNDELEIN IL NC11293656 03/27/2023
OAKLAND CA NC11297772 03/24/2023
OWATONNA MN NC11297955 03/23/2023
RICHMOND CA NC11297763 03/23/2023
SAN JOSE CA NC11297773 03/24/2023
SANTA BARBARA CA NC11291592 03/28/2023
SANTA CLARA CA NC11290813 03/24/2023
SCHENECTADY NY NC11305445 03/28/2023
SOUTH SEATTLE WA NC11297967 03/24/2023
SUNNYVALE CA NC11292052 03/24/2023
TAPPAN NY NC11290450 03/25/2023
WATSONVILLE CA NC11291605 03/24/2023
WHEELING IL NC11293660 03/26/2023
WHEELING IL NC11294607 03/27/2023
CAMPBELL CA NC11290875 03/24/2023
CENTRAL SEATTLE WA NC11297973 03/24/2023
NORTH SEATTLE WA NC11298157 03/24/2023
ARVADA CO NC11290373 03/26/2023
BUFFALO GROVE IL NC11293711 03/26/2023
CORTE MADERA CA NC11298159 03/23/2023
CUPERTINO CA NC11291553 03/24/2023
DES PLAINES IL NC11294509 03/25/2023
GLENVIEW IL NC11294504 03/26/2023
GRAND ISLAND NE NC11294521 03/27/2023
IOWA CITY IA NC11297529 03/25/2023
LOS GATOS CA NC11291546 03/24/2023
MILL VALLEY CA NC11298160 03/23/2023
NORTH WALES PA NC11296317 03/22/2023
SAINT PAUL MN NC11297860 03/24/2023
SAN CARLOS CA NC11298164 03/23/2023
SAN FRANCISCO CA NC11297864 03/24/2023
SOUTH SHORE - BOSTON MA NC11297721 03/24/2023
WATERTOWN WI NC11296556 03/22/2023
WAUKEGAN IL NC11293614 03/26/2023
WAYNESBORO VA NC11291790 03/17/2023
WHEELING IL NC11293706 03/26/2023
WILMETTE IL NC11293718 03/25/2023
APPLETON WI NC11296321 03/23/2023
AURORA CO NC11297870 03/24/2023
CAPITOLA CA NC11291515 03/24/2023
CEDAR RAPIDS IA NC11291946 03/22/2023
DAVENPORT IA NC11289974 03/23/2023
DENVER CO NC11297956 03/24/2023
DENVER CO NC11297959 03/24/2023
DENVER CO NC11297979 03/24/2023
DULUTH MN NC11302792 03/26/2023
GLENS FALLS NY NC11305507 03/28/2023
HIBBING MN NC11302779 03/26/2023
KANSAS CITY MO NC11297762 03/24/2023
LAFAYETTE CA NC11298966 03/23/2023
LAKE FOREST IL NC11294494 03/25/2023
LAKEWOOD CO NC11297958 03/24/2023
MADISON WI NC11297951 03/24/2023
MEDINA OH NC11291784 03/28/2023
MENLO PARK CA NC11298965 03/23/2023
MILPITAS CA NC11291557 03/24/2023
MISSION KS NC11297765 03/24/2023
MOUNT HOREB WI NC11296314 03/22/2023
NORTHBROOK IL NC11293552 03/26/2023
NORTHGLENN CO NC11297995 03/24/2023
REDWOOD CITY CA NC11298296 03/23/2023
RICHMOND CA NC11298971 03/23/2023
SAN MATEO CA NC11298167 03/23/2023
SAN RAFAEL CA NC11298161 03/23/2023
SANDY UT NC11305342 03/28/2023
SANTA CRUZ CA NC11291625 03/24/2023
SANTA ROSA CA NC11304471 03/28/2023
VALHALLA NY NC11296158 03/26/2023
GREATER BOSTON - BOSTON MA NC11297714 03/24/2023
AMES IA NC11289073 03/23/2023
NORTH SHORE - BOSTON MA NC11297752 03/24/2023
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Rural Carrier:
BROOKINGS SD NC11304416 03/27/2023
PULLMAN WA NC11289191 03/22/2023
MIDDLETON WI NC11294805 03/19/2023
MENOMONIE WI NC11294698 03/19/2023
MANITOWOC WI NC11294770 03/19/2023
MADISON WI NC11294682 03/19/2023
MADISON WI NC11294641 03/19/2023
HILLSBORO ND NC11304472 03/26/2023
ELDORA IA NC11304281 03/27/2023
EAU CLAIRE WI NC11294679 03/19/2023
EAU CLAIRE WI NC11294677 03/19/2023
BRIGHTON CO NC11304335 03/27/2023
AMERY WI NC11294788 03/19/2023
WILMINGTON NC NC11301218 03/25/2023
VERGENNES VT NC11301210 03/25/2023
PITTSFIELD NH NC11298031 03/23/2023
OTTUMWA IA NC11304280 03/27/2023
OSKALOOSA IA NC11304283 03/27/2023
MENOMONIE WI NC11294782 03/19/2023
MADISON WI NC11294795 03/19/2023
MADISON WI NC11294647 03/19/2023
LEBANON PA NC11297537 03/22/2023
HORACE ND NC11300532 03/24/2023
CLINTONVILLE WI NC11294692 03/19/2023
BRIGHTON CO NC11302512 03/25/2023
BALLSTON SPA NY NC11305443 03/26/2023
HUMBOLDT IA NC11304332 03/27/2023
YORK PA NC11296590 03/22/2023
SHIPPENSBURG PA NC11296593 03/22/2023
SCARBOROUGH ME NC11302736 03/26/2023
RUMNEY NH NC11297957 03/23/2023
HARRISBURG PA NC11296582 03/22/2023
DENVER PA NC11296596 03/22/2023
CHATTAROY WA NC11291846 03/22/2023
MADISON WI NC11294777 03/19/2023
​
Motor Vehicle Operator:
SPRINGFIELD IL P&DC NC11304272 03/27/2023
PORTLAND OR P&DC NC11302458 03/25/2023
SAN JOSE CA P&DC NC11302459 03/25/2023
SEATTLE WA P&DC NC11302460 03/25/2023
SYRACUSE NY P&DC NC11302215 03/25/2023
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Tractor Trailer Operator:
CHICAGO NDC NC11301112 03/25/2023
DENVER CO P&DC NC11302222 03/25/2023
DVD BLDG NJ P&DC NC11302090 03/25/2023
MORGAN NY P&DC NC11301120 03/25/2023
OAKLAND CA P&DC NC11302098 03/25/2023
PORTLAND OR P&DC NC11301306 03/25/2023
SAINT PAUL MN P&DC NC11302211 03/24/2023
SEATTLE NDC NC11302206 03/25/2023
SEATTLE WA P&DC NC11302223 03/25/2023
SO JERSEY NJ P&DC NC11301124 03/25/2023
NEW JERSEY NDC NC11301302 03/25/2023
TACOMA WA P&DC NC11302457 03/25/2023
BUSSE IL P&DC NC11301104 03/25/2023
SAN FRANCISCO P&DC NC11302202 03/25/2023
CAROL STREAM IL P&DC NC11301106 03/25/2023
CHICAGO INTL SVC CTR NC11301109 03/25/2023
MIDDLESEX-ESSEX P&DC NC11301115 03/25/2023
SALT LAKE CITY P&DC NC11305448 03/28/2023
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No experience necessary for the laborer custodial or maintenance mechanic positions. It helps on the interview but you can surely think of maintenance related experience to relay for an interview. Based on fixing things around your house, the car etc. Always mention working safely.
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Pro tip: You can apply for any job that has an exam opening and the test is administered local to yourself. Make sure you're serious and score decently; you can turn down the job offer. Keep a physical copy of your exam score, I believe they are good for two years.
The reason is: These job postings can be posted externally at capacity for testing, meaning they will not allow you to take the exam if they have enough qualified applicants. However, if you have a test score on the books, you are a qualified applicant.
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Explanation of MVO/TTO to save time:
MVO= CDL B Can only drive box trucks on public roads, can drive anything for moves on postal property.
TTO= CDL A Can drive anything.
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USPS provides the training. (Maintenance jobs at least. TTO and management...GOOD LUCK)
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You don't have to be crazy to work here. We'll train you. Everything but proper email usage.

Scientific Reports 7: 884 DOI:10.1038/s41598-017-00993-0 1 www.nature.com/scientificreports Endothelial and Astrocytic Support by Human Bone Marrow Stem Cell Grafts into Symptomatic ALS Mice towards Blood-Spinal Cord Barrier Repair Svitlana Garbuzova-Davis1,2,3,4, Crupa Kurien1, Avery Thomson1, Dimitri Falco1, Sohaib Ahmad1, Joseph Staffetti1, George Steiner1, Sophia Abraham1, Greeshma James1, Ajay Mahendrasah1, Paul R. Sanberg1,2,4,5 & Cesario V. Borlongan1,2 Vascular pathology, including blood-CNS barrier (B-CNS-B) damage via endothelial cell (EC) degeneration, is a recently recognized hallmark of Amyotrophic Lateral Sclerosis (ALS) pathogenesis. B-CNS-B repair may be a new therapeutic approach for ALS. This study aimed to determine effects of transplanted unmodified human bone marrow CD34+ (hBM34+) cells into symptomatic G93A mice towards blood-spinal cord barrier (BSCB) repair. Thirteen weeks old G93A mice intravenously received one of three different doses of hBM34+ cells. Cell-treated, media-treated, and control mice were euthanized at 17 weeks of age. Immunohistochemical (anti-human vWF, CD45, GFAP, and Iba-1) and motor neuron histological analyses were performed in cervical and lumbar spinal cords. EB levels in spinal cord parenchyma determined capillary permeability. Transplanted hBM34+ cells improved behavioral disease outcomes and enhanced motor neuron survival, mainly in high-cell-dose mice. Transplanted cells differentiated into ECs and engrafted within numerous capillaries. Reduced astrogliosis, microgliosis, and enhanced perivascular end-feet astrocytes were also determined in spinal cords, mostly in high-cell-dose mice. These mice also showed significantly decreased parenchymal EB levels. EC differentiation, capillary engraftment, reduced capillary permeability, and re-established perivascular end-feet astrocytes in symptomatic ALS mice may represent BSCB repair processes, supporting hBM34+ cell transplantation as a future therapeutic strategy for ALS patients. Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by gradual motor neuron degeneration in the brain and spinal cord leading to paralysis and fatality1 . About 50% of patients die within 30 months of disease symptom onset and only 20% of patients survive 5 to 10 years after symptom onset2 . Between 90–95% of ALS cases are sporadic (SALS) while the remaining 5–10% of cases are genetically linked or familial (FALS). Within FALS cases, several mutations in genes coding for Cu/Zn superoxide dismutase 1 (SOD1)3, 4 , TARDBP (TDP-43)5 , FUS/TLS6, 7 , ANG8 , and C90RF729, 10 have been identified and are discussed in comprehensive reviews11–13. The clinical presentation and underlying pathology of SALS and FALS are similar, and treatment options for ALS patients are mainly supportive. The only FDA approved drug to treat ALS is riluzole, which extends the lifespan of ALS patients by only a few months14. 1 Center of Excellence for Aging & Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, Florida, 33612, United States of America. 2Department of Neurosurgery and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, Florida, 33612, United States of America. 3 Department of Molecular Pharmacology and Physiology, University of South Florida, Morsani College of Medicine, Tampa, Florida, 33612, United States of America. 4 Department of Pathology and Cell Biology, University of South Florida, Morsani College of Medicine, Tampa, Florida, 33612, United States of America. 5 Department of Psychiatry, University of South Florida, Morsani College of Medicine, Tampa, Florida, 33612, United States of America. Correspondence and requests for materials should be addressed to S.G. (email: [email protected]) Received: 5 January 2017 Accepted: 17 March 2017 Published: xx xx xxxx OPEN www.nature.com/scientificreports/ Scientific Reports 7: 884 DOI:10.1038/s41598-017-00993-0 2 ALS is a complex multifactorial disease with numerous intrinsic and extrinsic factors underlying disease pathogenesis (reviewed in refs 15–24) such as glutamate excitotoxicity, mitochondrial dysfunction, oxidative stress, altered glial cell function, impaired axonal transport, protein aggregations, immune reactivity, neurotrophic factor deficits, and neuroinflammation. These multiple pathogenic effectors and the diffuse motor neuron degeneration in ALS present a formidable obstacle to treatment development for this disease. Accumulating evidence has demonstrated impairment of the blood-CNS barrier (B-CNS-B) in ALS and this barrier damage likely represents an additional pathogenic mechanism. Compelling results showed structural and functional alterations in the blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB) in ALS patients and in animal models of disease25–33. These studies demonstrated degeneration of endothelial cells (ECs) and astrocyte end-feet processes surrounding microvessels, impairment of endothelial transport system. Also, dysfunction of tight junction proteins has been implicated to compromise BBB/BSCB integrity. Additionally, vascular leakage, microhemorrhages, decreased capillary length and reduced blood flow have been shown in the spinal cords of ALS mice. Importantly, BSCB alterations were indicated in SOD1 mutant mice and rats prior to motor neuron degeneration and neuroinflammation29–31, suggesting vascular damage as an early ALS pathological event. These vascular pathologies, demonstrating impairment of neurovascular unit components in the brain and spinal cord, are key factors identifying ALS as a neurovascular disease34. It is possible that the initiating pathological trigger for ALS is a dysfunctional B-CNS-B, allowing detrimental factors from the systemic circulation to penetrate the CNS and foster motor neuron degeneration35. Since the damaged capillary endothelium in ALS does not adequately maintain vascular homeostasis in the CNS, repairing the altered B-CNS-B by replacement of endothelial cells via cell administration may be a new therapeutic approach for this disease. Bone marrow is a primary source of the putative EPCs but whether these progenitor cells are derived from hematopoietic stem cells or cells of endothelial lineage is still under debate (reviewed in refs 36–41). In terms of identifying the desired pro-angiogenic EPC lineage, it has been shown that EPCs are enriched in CD34+/CD45- cell populations and are not derived from CD133+ or CD45+ cells42. CD34+ cells are pluripotent hematopoietic stem cells, capable of long-term in vitro self-renewal and of differentiation into multiple hematopoietic cell lineages that fully repopulate blood cells throughout adulthood43, 44. However, lineage potential of the hematopoietic progenitors during proliferation, commitment to multipotential differentiation, and maturation are controlled by various intrinsic properties44 and microenvironmental factors. Additionally, transplanted bone marrow-derived CD34+ cells migrate and home into damaged tissue, as shown in treatment of patients with ischemic or degenerative retinal conditions45 or cardiomyopathy46 by contributing to revascularization via formation of new blood vessels from existing vascularity in ischemic tissues. Since EPCs are presumably derived from CD34+ cells, human bone marrow CD34+ (hBM34+) cells stand as a promising cell source for B-CNS-B restoration in ALS. We hypothesized that hBM34+ cells systemically transplanted into ALS mice induced BSCB repair by differentiating into endothelial cells. Whereas previous treatment-based studies have largely focused on pre-symptomatic ALS animal models, examining the effect of hBM34+ cells transplantation into a symptomatic mouse model of ALS increases the translational relevance to the clinic. The aim of this study was to decipher the mechanisms of BSCB repair promoted by unmodified human bone marrow CD34+ cells intravenously transplanted into symptomatic G93A SOD1 mice. A specific focus was determining transplanted cell differentiation potential and dose effects on motor function and motor neuron survival in cell-treated animals. Methods Ethics Statement. All described procedures were approved by the Institutional Animal Care and Use Committee at USF and conducted in compliance with the Guide for the Care and Use of Laboratory Animals. All mice were housed in a temperature-controlled room (23 °C) and maintained on a 12:12h dark: light cycle (lights on at 06:00 AM). Food and water were available ad libitum. Upon progression of neurological symptoms, a highly palatable liquid nutritional supplement was placed on the cage floor, ensuring access by the animal. Animals. All animals used in the study were obtained from The Jackson Laboratory, Bar Harbor, MA, USA. Seventy-two transgenic male B6SJL-Tg(SOD1*G93A)1GuJ mice, over-expressing human SOD1 carrying the Gly93→Ala mutation (G93A SOD1) at 7 weeks of age, were randomly assigned to one of four groups receiving different doses of hBM34+ cells or media: Group 1 - hBM34+ (5×104 cells/mouse, low dose, n=15), Group 2 - hBM34+ (5×105 cells/mouse, mid dose, n=15), Group 3 - hBM34+ (1×106 cells/mouse, high dose, n=21), and Group 4 - Media (n=21). At 8 weeks of age and then weekly, mice underwent pre-transplant behavioral testing (extension reflex, grip strength test, and rotarod) and monitoring of body weight. When initial disease symptoms appeared such as deterioration of motor function and reduction in body weight (approximately 13 weeks of age), mice intravenously (iv, jugular vein) received either the appropriate hBM34+ cell dose or an equal volume of media. A non-transplant control group (Group 5), consisting of non-carrier mutant SOD1 gene mice from the background strain (control, n=20), only underwent behavioral testing. At 14 weeks of age and weekly thereafter, mice again underwent behavioral testing until 17 weeks of age. Cell preparation and transplant procedure. Cryopreserved human bone marrow CD34+ cells (hBM34+, AllCells, Alameda, CA, USA) were thawed rapidly at 37 °C then transferred slowly with a pipette into a centrifuge tube containing 10ml of Dulbecco’s Phosphate Buffered Saline 1X (DPBS), pH 7.4 (Mediatech, Inc., Manassas, VA, USA). The cells were centrifuged (200 g/10min) at room temperature, the supernatant discarded and the process repeated. After the final wash, cell viability was assessed using the 0.4% trypan blue dye exclusion method before and after transplantation. Transplant cell concentrations were adjusted for each group: 250 cells/μl www.nature.com/scientificreports/ Scientific Reports 7: 884 DOI:10.1038/s41598-017-00993-0 3 (5×104 cells/200μl/injection, Group 1), 2,500 cells/μl (5×105 cells/200μl/injection, Group 2), and 5,000 cells/μl (1×106 cells/200μl/injection, Group 3). The hBM34+ cells were delivered intravenously via the jugular vein of mice under anesthesia with Isofluorane (2–5% at 2L O2/min) as we previously described47, 48 with minor modifications. Briefly, anesthetized animals received a sagittal incision at the base of the neck, and the jugular vein was identified. A 26-gauge needle was inserted into the jugular vein and needle placement verified by a reflux of blood into the syringe. A solution containing the cells was injected during 3min, and immediately following injection moderate pressure was applied onto the needle vein entry point using a sterile cotton tip. After transplantation, the incision was closed and sutured using monofilament nylon (Ethilon) or a stainless steel wound clip. To assure hemostasis, needle puncture was performed through the muscle overlying the jugular vein, allowing the muscle, combined with digital pressure, to facilitate bleeding stoppage. The media-injected mice in Group 4 received 200μl of DPBS, the same volume administered to the cell-transplanted mice. Animals in Groups 1–4 received cyclosporine A (CsA, 10mg/ kg ip) daily for the entire post-transplant period. Characteristics of disease progression. The evaluation of animal disease progression has been previously described47–49. All measures of animal disease progression were performed blind by independent investigators to avoid subjective bias. Body weight was assessed weekly throughout the study. Extension reflex, rotarod, and grip strength tests started on week 8 and were repeated weekly until 17 weeks of age. Extension Reflex. The mouse was suspended by the tail and the extension of each hindlimb was observed. If the mouse showed normal hindlimb extension, a score of 2 was given. A score of 1 indicated partial hindlimb extension. If no extension was observed, the score was 0. Grip strength test. The mouse was held by the tail and carefully placed with all 4 paws on the grid using an instrument to determine grip strength (IDTECH-BIOSEB, France). The animal was gently pulled by the tail and a sensor recorded the force (Newtons, N) with which the mice resisted the pull as a measure of muscle strength. The test was performed three times and the average of the tests was recorded. Rotarod. The mouse was placed on a 3.2 cm diameter axle rotating at a speed of 16 rpm (Omnitech Rotoscan, Omnitech Electronics, OH, USA). The latency (seconds) that the mouse stayed on the rotating axle during a 3minute maximum period was recorded. Perfusion and tissue preparation. All cell-treated, media-treated, and control mice were sacrificed at 17 weeks of age (corresponding to 4 weeks after initial treatment at symptomatic disease stage) for immunohistochemical analyses in the cervical and lumbar spinal cords for administered cell differentiation/engraftment and astrocyte expression. Histological analysis of surviving motor neurons was also performed in ventral horns of spinal cords. The mice (Group 3: n=4; Group 4: n=4) and controls (Group 5; n=5) were injected with 2% Evans Blue dye (EB, Sigma-Aldrich, St. Louis, MO, USA) in saline solution (4 ml/kg body weight) via the tail vein 30min prior to perfusion. Based on our previous studies showing that 1×106 stem cell dose is beneficial in treatment of animal models of ALS47 and mucopolysaccharidosis type III B50, spinal cord EB extravasation was evaluated only in mice receiving the high (1×106 ) cell dose vs. media and control animals. Mice were sacrificed under Euthasol® (0.22ml/kg body weight) and perfused transcardially with 0.1M phosphate buffer (PB, pH 7.2) followed by 4% paraformaldehyde (PFA) in PB solution under pressure control fluid delivery at 80–85mm Hg to avoid capillary rupture. Mice assayed for EB extravasation received only the PB solution. After perfusion, the entire spinal cords were rapidly removed for the EB extravasation assay described below. In remaining mice, the cervical and lumbar spinal cord segments were removed, post-fixed intact in 4% PFA for 24–48 hrs, and then cryoprotected in 20% sucrose in 0.1M PB overnight. Coronal spinal cord tissues were cut at 30μm in a cryostat, every fifth section was thaw-mounted onto slides, and the tissue was stored at −20 °C for immunohistochemical and histological analyses. BSCB permeability. Evans Blue (EB) dye, 961Da, was used as a tracer for assessing BSCB disruption. The EB extravasation assay was performed as previously described51–53. Briefly, after perfusion, mouse spinal cords were weighed and placed in 50% trichloroacetic acid solution (Sigma). Following homogenization and centrifugation, the supernatant was diluted with ethanol (1:3) and loaded into a 96 well-plate in triplicate. The dye was measured with a spectrofluorometer (Gemini EM Microplate Spectrofluorometer, Molecular Devices) at excitation of 620nm and emission of 680nm54. Calculations were based on external standards in the same solvent. The EB content in tissue was quantified from a linear standard curve derived from known amounts of the dye and was normalized to tissue weight (μg/g). All measurements were performed by two experimenters blinded to the experiment. Immunohistochemical staining of hBM34+ cells in the spinal cord. For identification of intravenously transplanted hBM34+ cell engraftment and differentiation potential, serial cervical and lumbar spinal tissue sections from randomly selected mice treated with different cell doses or media (n=5/group) were stained with human anti-Von Willebrand Factor (vWF), an endothelial cell marker, and CD45, a hematopoietic common leukocyte marker. Briefly, the mouse monoclonal antibody (vWF, 1:100, Abcam, USA) was combined with the secondary antibody, monovalent goat anti-mouse Fab’ fragment conjugated to FITC (1:200; Jackson ImmunoResearch, USA), and incubated at room temperature (RT) for 2 hours. The tissue sections were pre-incubated with 1% normal human serum (NHS) and 0.5% Triton 100X in PBS for 30 min at RT and subsequently incubated with the previously prepared antibody cocktail overnight at 4 °C. Next day, slides were www.nature.com/scientificreports/ Scientific Reports 7: 884 DOI:10.1038/s41598-017-00993-0 4 thoroughly washed in PBS and coverslipped with Vectashield containing DAPI (Vector Laboratories, USA). The tissues were then examined under epifluorescence using an Olympus BX60 microscope and images were taken for further analysis of vWF fluorescent immunoexpression. In a separate set of the cervical and lumbar spinal cord tissue sections (n=5/group), initial staining with the human-specific nuclei marker (HuNu) was performed as we described previously47–49. Briefly, the mouse monoclonal antibody (HuNu, 1:100, Chemicon, USA) was combined with the secondary antibody, monovalent goat anti-mouse Fab’ fragment conjugated to FITC (1:200; Jackson ImmunoResearch, USA), and incubated at room temperature (RT) for 2hours. Prior to applying this antibody cocktail overnight at 4 °C, the tissue sections were incubated in blocking solution for 30min at RT as described above. The next day, after several rinses in PBS, the tissues were placed in 10% normal goat serum (NGS) and 0.3% Triton 100X in PBS for 60 min at RT and then double-stained with mouse monoclonal antibody for CD45 (1: 200, BD Biosciences Pharmingen, USA) overnight at 4 °C. The next day, the slides were rinsed and goat anti-mouse secondary antibody conjugated to rhodamine (1:1000, Alexa, Molecular Probes, USA) was applied for 2 hrs at RT. After several rinses in PBS, the slides were coverslipped with Vectashield containing DAPI (Vector Laboratories, USA). The tissues were then examined under epifluorescence using an Olympus BX60 microscope. To test for specificity of the immunostaining for vWF and CD45, the primary antibodies were omitted from control slides. No staining was observed in the control sections. Immunohistochemical staining of astrocytes in the spinal cord. Serial sections of the cervical and lumbar spinal cord from randomly selected cell-treated, media-injected, and control mice (n=5/group) were rinsed in PBS to remove the freezing medium. The tissue sections were pre-incubated in a blocking solution of 10% NGS and 3% Triton 100X in PBS for 60min at RT, followed by overnight incubation with rabbit polyclonal anti-glial fibrillary acidic protein primary antibody (GFAP, 1:500, Dako, Denmark) at 4 °C. On the next day, slides were rinsed in PBS and incubated with goat anti-rabbit secondary antibody conjugated to FITC (1:500, Alexa, Molecular Probes, USA) for 2hrs at RT. After several rinses in PBS, the slides were coverslipped with Vectashield containing DAPI (Vector Laboratories, USA). The tissues were then examined under epifluorescence using an Olympus BX60 microscope and images were taken for further analysis of GFAP fluorescent immunoexpression. Immunohistochemical staining of microglia in the spinal cord. In a separate set of the cervical and lumbar spinal cord tissue sections from randomly selected cell-treated, media-injected, and control mice (n=3/ group), immunohistochemical staining for microglia was performed as we described previously48, 49 with minor modification. Briefly, tissue sections were rinsed in PBS to remove the freezing medium. The tissue sections were pre-incubated in a blocking solution of 4% NGS and 2% Triton 100X in PBS for 60min at RT, followed by overnight incubation with rabbit polyclonal anti-ionized calcium binding adapter molecule-1 primary antibody (Iba1, 1:500, Wako Chemicals, Richmond, VA, USA) at 4 °C. On the next day, slides were rinsed in PBS and incubated with goat anti-rabbit secondary antibody conjugated to rhodamine (1:500, Alexa, Molecular Probes, USA) for 2 hrs at RT. After several rinses in PBS, the slides were coverslipped with Vectashield containing DAPI (Vector Laboratories, USA). The tissues were then examined under epifluorescence using an Olympus BX60 microscope and images were taken for further analysis of Iba-1 fluorescent immunoexpression. vWF and astrocytic immunoexpression analyses in the spinal cord. Analyses of vWF and GFAP fluorescence immunoexpressions in the cervical and lumbar spinal cords from 17-week-old mice were performed in the ventral horns by an investigator blinded to the experiments. Animal codes were removed prior to analysis. Immunohistochemical image analyses for vWF and GFAP were performed by measuring intensity of fluorescent expression (%/mm2) in NIH ImageJ (version 1.46) software. Thresholds for detection of vWF and GFAP fluorescent expressions were adjusted for each image to eliminate background noise. To avoid bias in the analysis of fluorescent images, specific spinal cord areas were identified in a section using a 106/0.30 numerical aperture (NA) lens, and then areas of interest were photographed with either a 206/0.50 NA or 406/0.75 NA lens, photographing the slide in a random raster pattern. Briefly, measurements of cervical/lumbar ventral horn area were first performed by determining the cross-point of a line passing the central canal perpendicular to the midline. The area of ventral gray matter was determined below this line in the right and left cervical/lumbar spinal cords in coronal sections from each mouse group at predetermined uniform intervals (150mm). For detection of vWF immunopositive cells in cell-treated mice, immunohistochemical images (n=5 mice/group, n=8–10 images/ spinal cord segment) were taken in randomly selected areas from right and left ventral gray matter of the cervical and lumbar spinal cords at 40X. Fluorescent intensity (%/mm2 ) was measured in the entire image. Data are presented as averages of vWF cell immunoexpression of both sides. For GFAP intraparenchymal immunoexpressions in cell-treated, media-injected, and control mice, immunohistochemical images (n=5 mice/group, n=12–14 images/spinal cord segment) were taken from right and left ventral gray matter of the cervical and lumbar spinal cords at 10X. Density of astrocytes was determined as percentage per mm2 separately for the cervical and lumbar spinal cord sites as we previously described49. Also, fluorescent images of GFAP immunoexpression were taken of lateral and anterior white matter from both sides of the cervical/lumbar spinal cords at 10X for analyses. Additionally, GFAP perivascular immunoexpression was analyzed in the cervical/lumbar ventral horns of both sides from cell-treated, media-injected, and control mice. Fluorescent GFAP intensity of astrocytic end-feet (perivascular astrocytes) was measured adjacent to abluminal side of capillaries of approximately 25–30 µm in diameter (n=4–5 mice/group, n=14–16 capillaries/spinal cord segment). Density of perivascular GFAP immunoexpressions was determined as percentage per mm2 separately for cervical and lumbar spinal cord sites. Also, the proportion of reactive versus non-reactive astrocytes was observed based on cell morphology. Reactive astrocytes present larger cell bodies and thicker, easily visible processes, as opposed to non-reactive cells, which have more delicate features. www.nature.com/scientificreports/ Scientific Reports 7: 884 DOI:10.1038/s41598-017-00993-0 5 Histological staining and stereological count of motor neurons in the spinal cord. A separate set of cervical and lumbar spinal cord sections from randomly selected mice from each group (n =5/group) were stained with 0.1% cresyl violet using a standard protocol for examination of motor neuron condition for the Nissl substance. Motor neuron numbers in the ventral horn of the cervical and lumbar spinal cords were determined by the optical fractionator method of unbiased stereological cell counting techniques using a Nikon Eclipse 600 microscope and quantified by using Stereo Investigator® software (MicroBrightField). The virtual grid (150×150 µm) and counting frame (75×75 µm) were optimized to count at least 200 cells per animal with error coefficients <0.07. Outlines of the anatomical structures were done using 10X/0.45 objective, and cell quantification was conducted using 40X/1.40 objective. The motor neuron numbers (20–25 μm diameter) were counted in discrete levels of the cervical (C1–C3, C4–C6, and C7–C8) and lumbar spinal (L1–L2, L3–L4, and L5–L6) cords (n=7 sections/level/spinal cord segment/group separated by approximately 120 μm) and presented as averages per ventral horn for both spinal cord sides. Motor neuron morphologies were also analyzed in the cervical and lumbar spinal cords. Statistical analysis. Data are presented as means ± S.E.M. One-way ANOVA with Tukey’s Multiple Comparison test using GraphPad Prism software version 5 (GraphPad Software) was performed for statistical analysis. Significance was defined as p<0.05. Results The hBM34+ cells were intravenously administered into symptomatic G93A SOD1 mice (13 weeks old) at different doses and sacrificed at 17 weeks of age, corresponding to 4 weeks after initial treatment. Of the 64 total G93A SOD1 mice used in the study, five mice (Group 1 – one, Group 3 – three, Group 4 – one) were excluded due to death precipitated by conditions other than disease progression, more specifically, anesthetic complications during cell or media administrations. Also, four mice (Group 2 – one, Group 3 – one, Group 4 – two) were found dead at 16 or 17 weeks of age. Data on behavioral outcomes of these animals were included in analyses. Effect of hBM34+ cell transplantation at different doses on disease outcomes. Body weight, a general indicator of mouse health, and also a valuable marker for detecting progression of muscle atrophy, was measured weekly. As expected, body weight started to slowly decline at the symptomatic age of approximately 13–14 weeks in media-treated G93A mice and by 17 weeks of age, these mice had lost about 12% of their maximum body weight for this period. Although hBM34+ cell-treated animals lost weight more slowly, there were no significant differences between media and cell-treated mice at 1 week post-transplant. Significantly (p<0.05) higher body weights were determined in all cell-treated mice at 2 weeks post-transplant (15 weeks of age) compared to media-injected mice (Fig. 1A). At 3 and 4 weeks after cell transplantation (16 and 17 weeks of age), all cell-treated mice maintained significantly higher body weights (p<0.01) than media-injected mice. Of note, there were no significant differences in body weights between mice treated with different cell doses during the entire post-transplant period and at 17 weeks of age cell-treated mice weighed 2–2.5 grams more than media-injected mice. Cell-treated mice also displayed superior performance in tests of functional ability. Deteriorating extension reflex was noted in media-treated G93A mice, beginning at 12–13 weeks of age (1.93 ±0.03 and 1.88 ±0.04 score, respectively), with extension progressively declining until 17 weeks of age (1.13±0.13 score). However, hindlimb extension of mice treated with cells deteriorated more slowly than media-injected mice. At 16 weeks of age (3 weeks post-transplant), mice receiving cell transplantation displayed a tendency towards delayed deterioration of hindlimb extension compared to media-injected mice (Fig. 1B). At 17 weeks of age, only mice receiving 1×106 cells showed significantly (p<0.05) higher extension reflex scores vs. media-injected mice. Also, these mice demonstrated hindlimb extension scores (1.63±0.04) superior to mice receiving 5×104 cells (1.36±0.09) or 5×105 cells (1.39±0.08). In the grip strength test, media-treated G93A mice started to show decreased muscle strength at approximately 13 weeks of age (1,24±0.07 N), with strength progressively declining during the course of disease until 17 weeks of age (0,64±0.08 N) (Fig. 1C). Delayed loss in muscle strength was determined mainly in all cell-treated mice vs. media-injected at 15–16 weeks of age with significance (p<0.05) in mice with 5×105 cells (0,96±0.10 N) and 1×106 cells (1,01±0.13 N) at 17 weeks of age (Fig. 1C). Although muscle strength in mice receiving 5×104 cells (0.86±0.10 N) was superior to media-injected mice at 17 weeks of age, no significant difference between these groups was determined. Declines in performance on the rotarod test were observed in media-treated mice starting at week 13. Cell-treated mice demonstrated longer latencies for the entire post-transplant period vs. media-injected mice. At 17 weeks of age, ALS mice receiving 1 × 106 cells showed significantly (p < 0.05) higher rotarod latency (84.07 ± 23.22 sec) compared to media-injected (23.28 ± 6.25 sec) or other cell-treated mice (5 × 104 cells: 53.85±13.66 sec; 5×105 cells: 45.23±19.12 sec) (Fig. 1D). Importantly, at 16 weeks of age, 14, 19, or 22%, of mice transplanted with low, mid, or high cell dose respectively were able to complete the rotarod test (180 sec) while media-injected mice could not complete the test (Fig. 1E). At 17 weeks of age, about 6% of mice receiving the high 1×106 cell dose were the only animals to complete the test. Thus, intravenous transplantation of hBM34+ cells at different doses into symptomatic ALS mice ameliorated behavioral outcomes during 4 weeks post-treatment vs. media-injected mice by maintaining body weight and delaying losses in hindlimb extension, muscle strength, and rotarod performance. However, the most beneficial effect on motor function was determined in G93A mice treated with high 1×106 cell dose.

📷Live Setlist Thread
SHOW POSTER:
Paul Kreizenbeck
Doors: 6:30pm
Scheduled Start Time: 8:00pm ET (Instagram post says shortly after 8pm they will start)
OFFICIAL STREAM: Free for subscribers on Nugs.Net
UNOFFICIAL STREAM:
FANTASY GOOSE: https://airtable.com/shrNsjqPCNBQoYMaR
GOOSE DEDICATED THIS TOUR TO THE MEMORY OF CHUCK MORRIS, DONATE TO THE FAMILY HERE: https://www.gofundme.com/f/support-for-jenny-thompson-family
Tickets: Cash or Trade Goose Agora Cleveland
---
Start time: Walked on stage 8:39PM
Set 1 (8:40PM)
All I Need (Peter yells Yeah!) (25)
(Secret Agent Man Teas) The Whales 🐳(9)
Caution ⚠️(10)
Trevor Bass everyone 😎
JiveI (12)
California Magic 🪄(8) ➡️ JiveII (15) ➡️JIVE LEE (15) (with a Peter Laugh)
10:14 end set
Set 2 (10:52pm)
Drive 🏎️🏁 (8) ➡️Take on Me*➡️Cleveland Jam(15)
Into the Myst (16)
Honeybee with *Coach on a NEW Rainstick from the band (8)
Arrow🏹 (20)
end set 11:59pm
Encore (12:02am walked back on stage)
Peter thanks the crowd and Shaun for all the FOOD- Red's Steak House
Give it up for SCREEN
Shama Lama Ding Dong**
End Set 12:14am
Show Notes:
Jivefecta LTP Dallas TX 11/13/21 ( I think) double checking
*Take on Me- A-HA LTP 12/13/2019 (196 show gap)
**Shama Lama Ding Dong - Otis Day and The Knights (32 show gap)
PETER-O-METER:
[🔥 ] YEAH!
[🔥 ] Keyboard Warrior
[🔥 ] CLAV
[ 🔥] 2-Guitar Goose
[🔥 ] Time-traveling to the 80s
[ ] Backstage bananas
[🔥 ] Rocking
[ ] Arpeggiating
[ ] Floating
[🔥] Hip swangin'
[ ] "Are you freaking kidding me right now?"
[ ] Straight Bird'n
[ ] Channeling evil Goose
[ 🔥] Flipping switches
[ ] Razzle dazzle shoulders
[ ] Entering inter-dimensional travel
[🔥] Loving you guys
[ ] Summoning deep space aliens with a mating call
[ ] Crowd Participating
[ ] Wondering whose first Goose show it is
[ 🔥] Wizdini
SHOW INFO and SHENANIGANS
Night #1 of 1
Venue Info: The Agora
Weather: Cloudy, 49°F no meatballs in sight.
Check INs: Asheville, NC x3 🛋️Tour NYC San Rafael, CA The Agora x15 -first timer x3, Balcony Dead Center, Balcony 2nd Row, Balconyx2, Pete Side Rail, Trevor Side Balcony, FLOORx2, Balcony Pete Side, The Pit, Trevor Side Rail Morristown, NJ Chi-Town / Chigoose / The burbs x5 This Old Oregon Coast COVINGTON! Charlottesville, Va Chester, PA 🪣🔥 NOLA ⚜️ Williamsburg, VA Lansing, MI x3 Frederick, MD Toronto 🍁🫘town Nashville, TN Home of the NashCakes🥞Denver, CO x6 ATL / burbz x2😎 East Brunswick, NJSyraGoose x9 Portland, OR Memphis, TN Mother Goose from Dayton Rochester, NY x8 Houston, TX Stevens Point, WI Gilbert, AZ Rochester ➡️OHIO 🐈Columbus, OH Mechanicsburg PA SSI, GA Cincy, OH Madison WISCO x2 Augusta, GA Alameda, CA Chuck-Town, SC Philly, Philadelphia 🚱 x2 Baltimore County 🦀 Middletown CT Knoxville, TN Milwaukee/ Milwookie, WI x2 Grand Junction Colorado Boulder, Colorado Albany, NY x2 Wilton, CT Fort Worth, TX Newport Beach, CA 🏄‍♂️ Covington, KY — checkin’ in’ 🎧🎧👏💣🔥🧨x2 San Antonio, TX Birmingham, AL Seneca, SC Vernon, CT Austin, TX 🤠 San Diego, CA Skaneatles, NY Midlothian, Virginia Dallas, TX Baltimore, MD Shenandoah valley, VA Fanwood, NJ Kokomo, Indiana Seattle, WA Weathersfield VT The RVA Fair Lawn, NJ Prattville AL Annapolis, MD Fredricksburg,TX North Plainfield, NJ Richmond,VA Beaverton, Oregon Brooklyn, NYC🛋️🏄‍♂️WA Buffalo, NY Romeo, MI San Jose, CA Lakewood, CO West Side of Manhattan White Mountains, NH x2 Glastonbury, CT Kalama, WA Western NC🔥 Boston, MA Maywood, NJ DeKalb County, GA Collin County, TX Thank YOU TAPER from Columbus🔥 Standish, MEDFW area TX Boonton, NJ St. Paul, MN Frederick, CO Bay Area, CA Jackson, MS The Fabulous Las Vegas🎲🛀 Colorado Springs

This is a list of pit bull attacks documented on social media for the month of March 2023. This list will be edited throughout the month and after as new incidents are reported.
For attacks reported in the media and fatalities please see MARCH 2023 LIST.
TOTAL ATTACKS LOGGED: 303
CHILD FATALITIES:
ADULT FATALITIES: 7
ANIMAL FATALITIES: 60
TOTAL FATALITIES: 67
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March 01

Total: 0

March 02

Virginia, United States - golden doodle attacked - Link to Post
Dubuque, Iowa - person bitten by pit bull - Link to Post
San Antonio, TX - dog attacked by pit bulls - Link to Post
Unknown location - dog attacked by pit bull - Link to Post
United States - dog attacked by off leash pit bull - Link to Post

March 03

Colorado Springs, Colorado - dog attacked by pit bull - Link to Post

March 04

Denver, CO - attack on dog - Link to Post
Unconfirmed location - German shepherd attacked by 3 pits - Link to Post
Rock Springs, Wyoming - pit attacks another dog at dog park - Link to Post

March 05

North Carolina, United States - child bitten by family pit bull - Link to Post
Benton, Arkansas - 11 year old attacked by pit bull - Link to Post
Hampton, Virginia - dog attacked by pit bull - Link to Post
Glossop, England - Dalmatian attacked by pit bull - Link to Post
Omagh, England - (near miss) dog attacked by pit bull - Link to Post
Saratov, Russia - 11 year old boy bitten by pit bull - Link to Post

March 06

Honolulu, Hawaii - infant in stroller attacked by pit bull - Link to Post
Lake Worth, Florida - schnauzer attacked by pit bull - Link to Post
Unconfirmed location - dog attacked by pit bull - (images 7&8) -Link to Post

March 07

Parker City, Indiana - child attacked by pit bull - Link to Post
Trenton, GA - neighbor pit bull attacks child, no serious injuries - Link to Post

March 08

Unconfirmed location - pit mix bites owner’s friend - Link to Post
Dallas, Texas - person attacked by pit bull - Link to Post
United States - man bit by pit bull at groomers - Link to Post
Lactunga, Ecuador - dog attacked by pit bull - Link to Post
Anderson, Indiana - dog attacked by neighbors pit bull - Link to Post
Unconfirmed location – dog (Emma) attacked by three pit bulls and seriously injured – image 15 - Link to Post

March 09

North Carolina - person attacked by pit bull and was hospitalized - Link to Post
NSW, Australia - pit bulls attack one another, owner bitten - Link to Post
Columbus, Indiana - Maltese attacked by pit bull (breed confirmed) - slide 7 -- Link to Post
Vail, Arizona - dog attacked by pit bull, surgery required but dog survived - Link to Post
Indiana, United States - Maltese attacked by pit bull - Link to Post
NSW Australia - Animal attacked by pit bull - image 5 - Link to Post

March 10

Tuscaloosa, Alabama - goat attacked by pit bull - image 6 -Link to Post
Baltimore, Maryland - loose pit attacked another dog - image 10 - Link to Post
Unconfirmed location - 14 year old dachshund attacked by pit bull – image 4, 5 - Link to Post
Washington - dog attacked by pit bull - image 1 - Link to Post
Minnesota - person, another dog, and a cat attacked by pitbull - Link to Post

March 11

Unconfirmed location - woman (owner) and friend attacked - Link to Post
Washington State, United States - 17 month old “nipped” in the face by pit/rot mix - Link to Post
Unconfirmed location - woman and dog (Teddy) attacked while on walk - Link to Post
Rochdale, UK - dog attacked by pit bull (pit and run) - Link to Post
Louisiana - small dog attacked by neighbors pit bull - Link to Post
Maryland, United States - male bitten by pit bull in parking lot - Link to Post

March 12

Reno, Nevada - goats critically injured - image 02 - Link to Post
Beckenham, UK - dog attacked at dog park - image 03 - Link to Post
Columbus, Ohio - Man attacked by a friends pit bull - Link to Post
Blaine, Washington - Boston Terrier attacked by pit bull (both dogs have the same owner) - Link to Post
San Carlos, Mexico - golden doodle attacked by pit - Link to Post
Anderson, Indiana - dog attacked by pit bull - (image 8) - Link to Post

March 13

Pasco, Washington - dog attacked by pit bull - Link to Post
Georgetown, Ohio - miniature donkey attacked - (image 1) - Link to Post
Murray, Utah - woman and child attacked by two pit bulls - (image 3) - Link to Post
Comal County, Texas - male and female adult owners attacked by pit bull as well as another dog - image 13 - Link to Post
Belhaven, North Carolina - dog attacked by unrestrained pit bull - image 14, 15 - Link to Post

March 14

Metro Atlanta, Georgia - elderly lab attacked by pit bull - Link to Post
Toronto, Ontario - labernard puppy attacked by pit bull - Link to Post
Akron East, Ohio - elderly man and dog attacked by pit bull - Link to Post
Starkville, Mississippi - man attacked by family pit bull, sustained serious injuries - Link to Post
Lorain, Ohio - Chihuahua attacked by owner's American Bulldog - Link to Post
NSW Australia - Dog attacked by staffy - Image 03 - Link to Post

March 15

Watts, Texas - woman attacked by pit bull - image 3 - Link to Post

March 16

Ottowa, Ontario - man attacked by pit bull at bus stop - Link to Post
Charlotte, North Carolina – woman attacked by pit bull while walking her two dogs – image 5 - Link to Post
Danville, California – dog (Jasper) attacked while on walk by pit bull – image 19 - Link to Post
Proctorville, Ohio – man bitten and dogs attacked by white pit bull – image 20 - Link to Post
Saint Petersburg, Florida – small dog (Bella) attacked by neighbors pit bull, no serious injuries – image 13 - Link to Post
California - dog attacked by off leash pit bull - Link to Post

March 17

Unconfirmed location – dog attacked by pit bull – image 10 - Link to Post
Scranton, Pennsylvania – dog named ‘Burrito’ attacked by neighbors two dogs, one of which was a pit, Burrito was injured – image 12 - Link to Post
Aberdeen, United Kingdom – brown labradoodle was attacked by “bully type” – image 14 - Link to Post
Miles City, Montana – man and dog both attacked by the same pit bull – image 3 - Link to Post
Staten Island, New York – dog attacked by pit bull – image 1 - Link to Post
Unconfirmed location - man attacked by pit bull, sustained serious injuries and was hospitalized - image 4 - Link to Post

March 18

West Virginia – dog attacked by two pit bulls – image 1 - Link to Post
Richmond, Virginia - woman and small dog attacked, woman sustained a broken finger - Link to Post
Laramie, Wyoming - pit bull bit a person - image 12 - Link to Post
Minnesota - golden doodle attacked by pit at PetSmart - Link to Post

March 19

South Philadelphia, Pennsylvania - Shiba Inu attacked by off leash pit bull - image 1 - Link to Post
Michigan - woman bit, golden retriever attacked (status unknown) - Link to Post
New Orleans, Louisiana - man attacked by pit bull, owner of dog does a pit and run - Link to Post
Texas - 9 month old baby attacked by pit bull-lab mix - image 3 - Link to Post
Georgia - Dog named 'Prince' attacked - image 4 - Link to Post
Missouri - 6 month old puppy attacked by neighbor's pit bull - image 5 - Link to Post
Portland, Oregon - small dog 'Nelson' attacked by neighbor's pit bull - images 9-16 - Link to Post
Unconfirmed Location - woman attacked by husband's pit bull - Link to Post

March 20

Florida, United States - cat attacked by pit bull - Link to Post
North Carolina, United States - small dog named Louie attacked - image 9,10,11 - Link to Post
Kern County, California - pit bull attacked dog - image 17 - Link to Post

March 21

West Olive, Michigan - Woman attacked by pitbull, sustained minor injuries - Link to Post
Unconfimed location - dog attacked by pit bull resulting in serious injuries - image 12 - Link to Post

March 22

Round Lake, Illinois - dog and owner attacked by two off leash pit bulls - Link to Post
Hainault Country Park, England - Dog attacked by pit bull - image 8 - Link to Post

March 23

Washington, United States - pit bull attacks dog on bus and then bites owner - Link to Post
Reno, Nevada - woman caring for a dumped pit is attacked and left with severe facial injuries - Link to Post
Dallas, Texas - dog attacked by loose pit bull - video 3 of 3 - Link to Post
St. Tammany Parish, Louisiana - dog attacked by pit bull and sustained injuries - image 04 - Link to Post
Unconfirmed location - dog named 'Daisy' attacked by two pit bulls - image 7 - Link to Post
Pico Rivera, California - Loose pit bull attacks two dogs - image 12 -Link to Post

March 24

Ohio - child attacked by pit bull - Link to Post
St. Louis, Missouri - owner attacked - Link to Post

March 25

Mississippi - dogs (2) attacked by loose pit bull - image 13 - Link to Post
Australia, Townsville Queensland - Great Dane attacked by staffie - Link to Post

March 26

Havering-atte-Bower, England - Dog attacked - image 05 - Link to Post
Dallas, Texas - Dog attacked by pit bulls - Link to Post

March 27

Unconfirmed Location - Dog named Otto attacked by pit - image 03 - Link to Post

March 28

Virginia, United States - Dog attacked - Link to Post
Australia - Dog and owner attacked by pit - Link to Post
Tennessee - male attacked by pit Link to Post
Austin, Texas - dog attacked by pit housemate - Link to Post

March 29

dog mauled by pit bull - Link to Post

March 30

March 31

Austin, Texas - dog attacked - Link to Post

Unconfirmed dates

Please see pinned comments below

There's a lot going on this weekend and even better the weather forecast looks great with 60s and 70s and only a little rain on Saturday morning.
Here's 35 local events you can enjoy at Virginia Tech, in Blacksburg and throughout the New River Valley:
1. Pink Moon Peach Milkshake IPA Release Moon Hollow Brewing, Blacksburg Friday, March 24, 2023, 3:00 - 10:00 PM Admission is free. Beer and food are regular price. Moon Hollow Brewing presents the Pink Moon Peach Milkshake IPA Release in support of the local Pink Boots Society. This year’s blend contains Loral, Eukanot and HBC 586. A heaping dose of lactose, peach purée and vanilla bean also help create a rich and delicious brew. $1.00 from each pint is donated the Pink Boots Society Blue Ridge Virginia Chapter. This helps the chapter continue to put on educational, community enriching events. The Pink Boots Society aims to assist, inspire and encourage women and non-binary individuals in the fermented/alcoholic beverage industry to advance their careers through education. Food will be available for purchase from Countryman Jamaican Grill. Link: http://www.nextthreedays.com/FeaturedEventDetails.cfm?E=685855
2. Root Down in Concert Rising Silo Farm Brewery, Blacksburg Friday, March 24, 2023, 6:00 - 9:00 PM Admission: Free Root Down is a jazz trio based in the New River Valley. Link: http://www.nextthreedays.com/FeaturedEventDetails.cfm?E=684803
3. College Softball: Chattanooga vs. Virginia Tech Tech Softball Park, Virginia Tech Friday, March 24, 2023, 6:00 - 8:00 PM, Saturday, March 25, 2023, 12:00 PM and 2:00 PM (Doubleheader) Admission: Free Watch the Virginia Tech Softball team compete against non-conference opponent the University of Tennessee Chattanooga in a three game series. No tickets are required for Hokie Softball games. Parking is available behind the outfield at Tech Softball Park and enter along the right field side of the stadium. Stands open one hour prior to the start of the game. Link: http://www.nextthreedays.com/FeaturedEventDetails.cfm?E=685859
4. Music Theatre: "Book of Mountains and Seas" Moss Arts Center at Virginia Tech, Blacksburg Friday, March 24, 2023, 7:30 - 9:00 PM Adult Tickets (based on seat location): $25.00 - $55.00 Virginia Tech Students with ID and Youth 18 & Under: $10.00 A daring new music theatre work by composer Huang Ruo and puppeteer, designer, and director Basil Twist, "Book of Mountains and Seas" is a modern take on ancient Chinese creation myths that are relevant to our current climate change struggle, featuring the chorus of Ars Nova Copenhagen alongside massive puppets and striking lanterns. The work is sung in Mandarin with English supertitles. Book of Mountains and Seas is inspired by the ancient Chinese compilation of early myths of the same title, which was first transcribed in 4th-century B.C. Book of Mountains and Seas is a 21st-century adaptation and expansion of four of these tales. The work contains timeless codes about the universe, creation, planet, nature, life, human ambition and fate, the relationship and interaction between mankind and the planet. Link: http://www.nextthreedays.com/FeaturedEventDetails.cfm?E=678174
5. Will Easter & The Nomads in Concert Dogtown Roadhouse, Floyd Friday, March 24, 2023, 8:00 - 11:00 PM Admission: $8.00 Will Easter has one of those voices that is like a home-cooked meal for the soul. Will has the cool throwback rock edge of Tom Petty with the modern folk-Americana appeal of the Avett Brothers, but with something hard to put your finger on that could only be born out of the shadows and peaks of the North Carolina mountains. One iteration through a chorus and you’ll find yourself humming along, by the second time around you’ll be singing out loud, ready to hit the repeat button. Link: http://www.nextthreedays.com/FeaturedEventDetails.cfm?E=684795
6. Juxtaposition A Cappella Spring 2023 Concert: Time For A Hoedown Haymarket Theater (Squires Student Center), Virginia Tech Friday, March 24, 2023, 8:00 - 9:30 PM Virginia Tech Students: At the Door: $7.00 Non-Students: $10.00 Juxtaposition A Cappella presents their Spring 2023 Concert titled "Time For A Hoedown". Juxtaposition will be performing seven new songs including their entire ICCA set. Juxtaposition is an all-male Virginia Tech A Capella group that was established in 1994 and has since produced seven albums and been awarded numerous awards and honors. They enjoy performing their wide repertoire of 70's, 80's, 90's and current hits. Link: http://www.nextthreedays.com/FeaturedEventDetails.cfm?E=685879
7. 2023 Ramp N Roads Eastern Elementary/Middle School, Pembroke Saturday, March 25, 2023, 8:30 AM - 12:30 PM Admission: Free Renew the New presents the 2023 Ramp N Roads where volunteers will be cleaning up litter from highways and byways, boat ramps, and river & stream access points. Be prepared to pick up litter off road in ditches and over the banks. Each volunteer will be assigned a team who will be led by captain when they arrive at Eastern Elementary/Middle School. These captains will lead the on-site clean up and will provide any needed safety instructions. There will be no buses running this year. Each volunteer will take their own car or carpool and convoy to one of the planned cleanup areas. There you will be given gloves and bags to use. Each volunteer is asked to return to Eastern Elementary at noon where they will receive pizza for a to-go lunch and a t-shirt. Volunteers need to sign up in advance. This is a rain or shine event however pick up along roadways will be suspended during active rain if it happens. ReNew The New is a volunteer organization committed to stewardship of the of the New River flowing through Southwest Virginia. Link: http://www.nextthreedays.com/FeaturedEventDetails.cfm?E=685871
8. Yoga On Tap with Blacksburg Yoga Collective Rising Silo Farm Brewery, Blacksburg Saturday, March 25, 2023, 9:30 - 10:45 AM Suggested donation of $15.00-$20.00. The Blacksburg Yoga Collective presents Yoga On Tap with an energizing and uplifting flow. Flow with Blacksburg Yoga Collective in the beautiful settings of the Rising Silo Saturdays. These Kundalini-inspired, donation-based Yoga and meditation sessions focus on therapeutic movements and various breathing techniques aimed toward collective wellness. Meditate, chant, and move together to ease stress, manifest positivity, and improve our awareness and focus. Admission includes the class and a post-yoga non-alcoholic beverage from the brewery. Link: http://www.nextthreedays.com/FeaturedEventDetails.cfm?E=685840
9. 2023 Warm Hearth Village Arts & Crafts Fair Warm Hearth Village Center, Blacksburg Saturday, March 25, 2023, 10:00 AM - 5:00 PM Admission: Free If you love unique, beautiful, locally handcrafted gifts and art, then attend the 2nd Annual Warm Hearth Village Arts & Crafts Fair. The show will feature high-quality artisanal goods from both artists on our campus and throughout the New River Valley. Handmade items for sale will include pottery, woodworking, home goods, accessories, soaps, candles & more. The Huckleberry Cafe will be open for grab-n-go refreshments. Link: http://www.nextthreedays.com/FeaturedEventDetails.cfm?E=683666
10. Free Wine Tasting Vintage Cellar, Blacksburg Saturday, March 25, 2023, 11:00 AM - 4:00 PM Admission: Free Vintage Cellar presents Free Wine Tasting every Saturday from 11:00 AM to 4:00 PM. Join them for a decadent wine tasting at our free wine tasting. They will teach you all about the regions and grapes from the wines as you taste. After the tasing, grab a bottle or glass and enjoy it with some food from their kitchen. Must be 21 or older to participate. IDs required. Link: http://www.nextthreedays.com/FeaturedEventDetails.cfm?E=685724
11. Open Virginia Tech Football Practice Lane Stadium, Blacksburg Saturday, March 25, 2023, 11:45 AM - 1:00 PM Admission: Free Fans are invited to attend the open practice to get an early look at how the Hokie's 2023 football squad is shaping up. Gate 6 will open up at 11:45 AM for fans to enter. Note: It is prohibited for fans to take photos and videos when the Hokies are on the field. Link: http://www.nextthreedays.com/FeaturedEventDetails.cfm?E=685711
12. 2023 Beliveau Bridal Expo Beliveau Farm Winery, Blacksburg Saturday, March 25, 2023, 12:00 - 4:00 PM Admission: Free Bring your friends and family and visit with the area's leading wedding professionals on display to plan your perfect wedding in an elegant venue. Wedding vendors such as florists, musicians, photographers, bakeries and more will set up in our Great Hall to talk to you about their services. This is a great opportunity to meet many of the vendors in one afternoon. Food and wine will be available to purchase throughout the entire event. Link: http://www.nextthreedays.com/FeaturedEventDetails.cfm?E=684117
13. Women's Lacrosse: Boston College vs. Virginia Tech Thompson Field, Virginia Tech Saturday, March 25, 2023, 12:00 - 2:00 PM Admission: Free Watch the Virginia Tech Women's Lacrosse compete against ACC conference opponent and #7 ranked Boston College. Link: http://www.nextthreedays.com/FeaturedEventDetails.cfm?E=684297
14. Program: Vegetable Gardening Meadowbrook Public Library, Shawsville Saturday, March 25, 2023, 1:00 - 2:00 PM Admission: Free Want to grow your own vegetables, but aren’t sure where to start? Join Dr. Emma Patterson, VCE Volunteer Master Gardener, to find out more about planning a vegetable garden, caring for it, and keeping it going through year’s end. Free seeds and soil testing kits will be provided. For ages 12 and up. Link: http://www.nextthreedays.com/FeaturedEventDetails.cfm?E=685348
15. 2023 Oyster Dinner Drive-Thru Riner Volunteer Fire Department, Riner Saturday, March 25, 2023, 2:00 - 6:00 PM Admission: $15.00 The Riner Volunteer Fire Department presents their Annual Oyster Dinner Drive-Thru featuring fried oysters, baked beans, slaw and dessert. Tickets can be purchased in advanced at Eagle Express, Riner Food Center and Village Barber Shop. Link: http://www.nextthreedays.com/FeaturedEventDetails.cfm?E=685387
16. Delta Chi's Into the Wild Benefit Concert featuring Audio Fever and The Red Ferns The Milk Parlor, Blacksburg Saturday, March 25, 2023, 2:00 - 5:00 PM Ages 21 & Over: $9.00, Ages 20 & Under: $12.00 The Delta Chi Fraternity at Virginia Tech presents their Into the Wild Benefit Concert featuring music from Audio Fever and The Red Ferns. Proceeds from ticket sales will go towards the V Foundation for Cancer Research. The Red Ferns is a groovy guitar band based in Blacksburg and Audio Fever is a Blacksburg based band as well. Link: http://www.nextthreedays.com/FeaturedEventDetails.cfm?E=685882
17. March Flashlight Tour St. Albans, Radford Saturday, March 25, 2023, 5:30 - 7:30 PM Admission: $15.00 Join St. Abans for their March 2023 Flashlight Tour which includes a little history and paranormal in one. This is a guided tour. Take a walk through the dark halls of St. Albans Sanatorium and join them for a flashlight tour of the building. Hear all the chilling tales of what paranormal investigators, and the public, have encountered within these 120 year old walls. A little bit of history, a little bit of paranormal. Tickets are available online in advance and will be sold at the door provided tickets are still available. Comfortable shoes and a flashlight are recommended as there will be lots of walking and many dark areas. Dress accordingly as the building is not climate controlled. You must be 18 years of age (16 if accompanied by a parent or legal guardian). Link: http://www.nextthreedays.com/FeaturedEventDetails.cfm?E=685883
18. March's Beans and Banjos (Final Event) Meadowbrook Public Library, Shawsville Saturday, March 25, 2023, 6:00 - 8:00 PM Admission: $5.00 requested donation The Shawsville Ruritans and The LINC Letter presents March's Beans and Banjos and the final event of this series. Nothing lasts forever, not even Beans and Banjos. March's Beans and Banjos will be the last. Instead of having a couple of bands the organizers are inviting everyone who's ever played or sung at Beans and Banjos to come out and jam to play Beans and Banjos out in style. Beans and Banjos has been going for at least 14 years. Enjoy a dinner of beans, cornbread and desserts. Organizers ask for a donation of at least $5.00 to help keep the LINC Letter publishing. The LINC Letter is the non-profit community newsletter for Eastern Montgomery and is distributed to residents of Alleghany, Elliston, Ironto, Lafayette and Shawsville, Virginia. Link: http://www.nextthreedays.com/FeaturedEventDetails.cfm?E=685325
19. Amelia Empson in Concert Rising Silo Farm Brewery, Blacksburg Saturday, March 25, 2023, 6:00 - 9:00 PM Admission: Free Amelia Empson plays a variety of Indie-Folk and Americana covers and originals from the Appalachian Mountains with talent far beyond her years. Link: http://www.nextthreedays.com/FeaturedEventDetails.cfm?E=684804
20. Salsa Night 2023 Beliveau Farm Winery, Blacksburg Saturday, March 25, 2023, 7:00 - 11:00 PM Advance Tickets: $12.00, At the Door: $15.00 Join Beliveau Farm Winery for a dancing experience with your loved one, group of friends, or come single; you are bound to have a good time no matter what. Lessons begin at 7:00 PM and the event lasts until 11:00 PM. Link: http://www.nextthreedays.com/FeaturedEventDetails.cfm?E=685126
21. 2023 March of Ales Mardi Gras Celebration German Club Manor, Virginia Tech Saturday, March 25, 2023, 7:00 PM - 12:00 AM Admission: $50.00 The Blacksburg Junior Women's Club (BJWC) presents the 2023 March of Ales Mardi Gras Celebration featuring unique beers for tasting, along with wine and a signature cocktail. Coffee, water, lemonade, hors d’oeuvres and desserts will also be available. Guests will enjoy entertainment by a DJ, dancing, and a live and silent auction. The auctions feature an extraordinary variety of items donated by local businesses and individuals. At the end of the evening, discounted Uber service will be available to guests. Tickets will be available for purchase at the door if the event is not sold out in advance. All money raised at March of Ales is used to fund service projects and donations throughout the year. The funds have benefitted groups and causes such as Special Olympics, Salvation Army, Ronald McDonald House, Montgomery County Christmas Store and many others. Link: http://www.nextthreedays.com/FeaturedEventDetails.cfm?E=685695
22. WUVT's Jazz Night with Copy Cat Syndrome and Yung LZRD Odd Fellows Building Lodge #20 (Wilson Avenue), Blacksburg Saturday, March 25, 2023, 7:00 - 10:00 PM Admission: $6.00 Join WUVT for a night filled with the sweetest jazz melodies provided by Copy Cat Syndrome and Yung LZRD. Copy Cat Syndrome is a fusion trio performing jazz based in Blacksburg, VA. LZRD is a jazz band from Blacksburg, VA. Entrance to this event is ticket only (sold online) with a maximum of 50 being sold. Doors open at 6:00 PM and the music starts at 7:00 PM. WUVT-FM 90.7 Blacksburg is the New River Valley's only source for independent, alternative programming. Link: http://www.nextthreedays.com/FeaturedEventDetails.cfm?E=685887
23. TechNotes Spring 2023 Concert: TechNotes Lightnin’: Feeling the 50s Haymarket Theater (Squires Student Center), Virginia Tech Saturday, March 25, 2023, 7:00 - 8:30 PM Advance Tickets: $5.00, At the Door: $7.00 TechNotes presents their Spring 2023 Concert titled "TechNotes Lightnin’: Feeling the 50s". Enjoy a night full of new songs and old TechNotes favorites and chances to win epic raffle prizes. TechNotes is a co-ed A Cappella group at Virginia Tech that performs at various events throughout the year. TechNotes was founded in 2010. Link: http://www.nextthreedays.com/FeaturedEventDetails.cfm?E=685878
24. Caroline Owens & Company in Concert Floyd Country Store, Floyd Saturday, March 25, 2023, 7:00 - 10:00 PM General Admission: $15.00, Reserved Seating: $20.00 Caroline Owens is a 2X IBMA nominated Bluegrass and Gospel artist. She has performed alongside many of her heroes such as Alison Krauss, Suzanne Cox, The Isaacs, Larry Gatlin, Darin & Brooke Aldridge, Lorraine Jordan and many others. And, has made quite a name for herself in the North Carolina bluegrass community. Link: http://www.nextthreedays.com/FeaturedEventDetails.cfm?E=685713
25. Hoppie Vaughan & The Ministers of Soul in Concert The Floyd Center for the Arts, Floyd Saturday, March 25, 2023, 7:30 - 9:30 PM General Public: $15.00, Students: $10.00 Don't miss your chance to see the long awaited return of Hoppie Vaughan & The Ministers of Soul. It will be a fun, funky night of soul. The diversely talented Hoppie Vaughan is all about the soul! He is a blue eyed soul singer, song writer, guitar and bass player. Besides performing solo, he is the front man for Hoppie Vaughan and the Ministers of Soul based out of Roanoke, VA performing classic soul, R&B, blues and funk. Link: http://www.nextthreedays.com/FeaturedEventDetails.cfm?E=685712
26. Three Band Concert with Kenny Vaughan, Sullivan Smith & Stray Lions and Friend of the Three Southpaw Cafe & Community Space, Blacksburg Saturday, March 25, 2023, 7:30 - 10:00 PM Admission: $5.00 Southpaw Cafe & Community Space presents a Three Band Concert with Kenny Vaughan, Sullivan Smith & Stray Lions and Friend of the Three. Friend of the Three is a band based in Virginia that performs adult alternative, pop and rock. Link: http://www.nextthreedays.com/FeaturedEventDetails.cfm?E=685881
27. Stand-Up Comedy Show Lost In Taste, Christiansburg Saturday, March 25, 2023, 10:00 PM - TBD Admission: $7.00 The Cosmic Comedy Club returns with performances by comedians Sage Delong, Derek Budd, Julia Goyer, Tony Rodriguez, Jermaine Callando and hosted by Andrew Gustafson. Recommended for ages 18 & up. Link: http://www.nextthreedays.com/FeaturedEventDetails.cfm?E=685853
28. 2023 Hot Diggity Dog Day (Fun for Your Dog) Beliveau Farm Winery, Blacksburg Sunday, March 26, 2023, 12:00 - 6:00 PM Admission: Free Bring your pup and come have a day at Beliveau Farm Winery annual canine event. There's 165 acres of dog fun for your furrr-ever friend to explore and relax. Fresh air, dog parade, lots of outdoor space. Beliveau will have food and drinks for purchase throughout the day. With every hot-dog sold, they are donating 20% of our proceeds to the Montgomery County Humane Society. Link: http://www.nextthreedays.com/FeaturedEventDetails.cfm?E=685322
29. Community Quilting Bee: Rotary Cutting Fabric Blacksburg Library, Blacksburg Sunday, March 26, 2023, 1:00 - 3:00 PM Admission: Free Blacksburg Library presents their monthly Community Quilting Bee with the the topic "Rotary Cutting Fabric". This month atteneeds will learn how to use a rotary cutter and ruler to make accurate fabric pieces. Everyone is welcome including beginners. Link: http://www.nextthreedays.com/FeaturedEventDetails.cfm?E=685349
30. Book Club: The Winemaker Blacksburg Wine Lab, Blacksburg Sunday, March 26, 2023, 1:00 - 3:00 PM Admission: $40.00 Join the Blacksburg Wine Lab for the Wine Lab Book Club tasting & discussing featuring "The Winemaker" by Noah Gordon. About The Winemaker: Josep Alvarez is a young man in the tiny grape-growing village of Santa Eulália, in northern Spain, where his father grows black grapes that are turned into cheap vinegar. Joseph loves the agricultural life, but he is the second son, and his father’s vineyard will be inherited by his brother Donat, the firstborn. He yearns for a job growing grapes and for an opportunity to marry Teresa Gallego. In Madrid, an assassination plot, conceived against the political leader of Spain by men of wealth and power, creates a storm of intrigue that sucks into its vortex a group of innocent young farm workers in Santa Eulália. How Josep’s life is changed drastically by these events, and how, ironically, they gradually turn him into an inspired vintner with an evolving vision of life, is the fascinating story of "The Winemaker". During the Book Club, enjoy four fantastic Spanish wines to taste. Chef Bryan will create a pairing board of house–made Spanish tapas, cheese and charcuterie to accompany the tasting. Reservations required. Link: http://www.nextthreedays.com/FeaturedEventDetails.cfm?E=685385
31. Willard Gayheart and Ricky Cox performing "Old Favorite Songs of the Blue Ridge" Floyd United Methodist Church, Floyd Sunday, March 26, 2023, 2:30 - 3:30 PM Admission: Free The Floyd County Historical Society presents an encore performance of Willard Gayheart and Ricky Cox performing "Old Favorite Songs of the Blue Ridge. Ricky Cox’s friendship with Willard Gayheart also goes back 35 years. This shows in the programs they present together, harmonizing and appreciating one another’s contributions as they delight their audiences. Willard is a pencil artist from Southwest Virginia. He is originally from Eastern Kentucky, working mostly from the theme "Nostalgic Glimpses of the Appalachians". His works are positive images of Appalachian Culture, presenting the region as a place alive with interesting personalities. Besides his artistic talent with the pencil, Willard is also an accomplished bluegrass musician having played as a member of the bluegrass band The Highlanders. Ricky Cox has been entertaining and educating many of us for decades. Throughout his teaching career at Radford University he shared the history and culture of our region through his music and writing, earning a number of special recognitions along the way. Ricky contributed his photographic talents to the second of two books featuring Willard Gayheart’s drawings. Note: The event was originally scheduled for Sunday, March 12th, but had to be postponed due to inclement weather. Link: http://www.nextthreedays.com/FeaturedEventDetails.cfm?E=685328
32. Blacksburg Community Band Spring Concert Blacksburg High School Auditorium, Blacksburg Sunday, March 26, 2023, 3:00 - 4:00 PM Admission: Free The Blacksburg Community Band presents their Spring Concert conducted by David McKee and Associate Conductor, Dean Chiapetto. Christiansburg High School's band director, David Miller, will be guest conducting. Jefferson Ritchie will solo on trombone. The Blacksburg Community Band, Inc. is an all-volunteer community organization formed in 1989 under the auspices of the Department of Parks and Recreation in the Town of Blacksburg. The ensemble is open to individuals of all ages and ability levels from the New River Valley and surrounding areas. Link: http://www.nextthreedays.com/FeaturedEventDetails.cfm?E=685314
33. Helping Hands Fundraiser with Spaghetti Dinner and Live Music Belview United Methodist Church, Radford Sunday, March 26, 2023, 4:30 - 7:30 PM Donations Appreciated Join Belview United Methodist Church for some fun and great fellowship all while helping support a wonderful mission. Help them fund their Helping Hands Pantry by enjoying a spaghetti dinner starting at 4:30 PM, silent auction, raffle and live music from Eddie & Sherry Richards and Spoken For beginning at 6 PM. Belview's Helping Hands Pantry supplies clothes, personal care items, cleaning items and household items to those in need in Montgomery County, Radford, Dublin, Giles County and Pulaski and other surrounding areas. The Silent Auction starts at 1:30 PM and ends at 7:30 PM with over 40 items to bid on. There are over $2,000 in prizes for the raffle. Raffle tickets are $5.00 each, $10.00 for three or $20.00 for seven. Donate a pack of diapers, pull-ups or Depends and get three free raffle tickets on the day of the event. Link: http://www.nextthreedays.com/FeaturedEventDetails.cfm?E=685880
34. Indian Run Stringband in Concert Palisades Restaurant, Eggleston Sunday, March 26, 2023, 5:00 - 7:30 PM Admission: Free The Indian Run Stringband from Blacksburg, VA plays fiddle and banjo foot stomping dance tunes and sings traditional songs with old time harmonies perfect for dancing the two step. From dance tunes to the blues, the Indian Run Stringband plays with love and abandon. They make old-time music fresh and new. Link: http://www.nextthreedays.com/FeaturedEventDetails.cfm?E=685310
35. Virginia Tech Percussion Ensemble in Concert with Guest Artist Michael Burritt Moss Arts Center at Virginia Tech, Blacksburg Sunday, March 26, 2023, 6:00 - 7:30 PM General Public: $15.00, Seniors: $12.00, Students & Youth: $10.00 The Virginia Tech Percussion Ensemble, under the direction of Annie Stevens, performs a concert with guest artist Michael Burritt who is one of his generation’s leading percussionists. He is in frequent demand, performing concert tours and master classes throughout the United States, Europe, Asia, Australia and Canada. He has been soloist with the United States Air Force Band, Dallas Wind Symphony, Omaha Symphony, Chautauqua Symphony Orchestra, Richmond Symphony Orchestra, Ju Percussion Group (Taiwan), Percussion Art Quartet (Germany) and the Amores Percussion Group (Spain). Link: http://www.nextthreedays.com/FeaturedEventDetails.cfm?E=685872
Have a great weekend and thanks for reading!